Evidence map›Paper›PMID 27080521›Full record

ArticleNature reviews. Neurology2016

HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment.

Deanna Saylor, Alex M Dickens, Ned Sacktor, Norman Haughey, Barbara Slusher, Mikhail Pletnikov, Joseph L Mankowski, Amanda Brown, David J Volsky, Justin C McArthur

Abstract readPublished Erratum
In one paragraph

Article in Nature reviews. Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Neurology(R) neuroimmunology & neuroinflammation · 2026
    Trial
  8. Antiretroviral Therapy Intensification for Neurocognitive Impairment in Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Neuroimmune Correlates of HIV and Marijuana Use: Peripheral Biomarkers and Cognitive Function.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  15. Article
  16. Population Analysis and Immunologic Landscape of Melanoma in People Living with HIV.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  17. Epigenetic mechanisms of HIV and opioid-induced neuropathology: Potential therapies and interventions.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  18. Article
  19. Review
  20. Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Deanna Saylor
Alex M Dickens
Ned Sacktor
Norman Haughey
Barbara Slusher
Mikhail Pletnikov
Joseph L Mankowski
Amanda Brown
David J Volsky
Justin C McArthur

Funding

Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Barbara Stauch Slusher · 2006 to 2026
$33.2M
Surrogate Marker CoreP01MH105280 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HAUGHEY, NORMAN J, MCARTHUR, JUSTIN CHARLES. · 2015 to 2019
$6.5M
Toward a Mouse Model of HIV-1 Infection and Drug AddictionR01DA017618 · NIDA · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI POTASH, MARY JANE, VOLSKY, DAVID J · 2004 to 2015
$6.2M
Threshold of Cognitive Impairment after HIV Infection: Effect of MorphineR01DA037611 · NIDA · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI VOLSKY, DAVID J · 2014 to 2018
$4.0M
CNS Reservoirs of HIV in a Mouse Model of HIV Infection and Cognitive Impairment:R01MH104145 · NIMH · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI VOLSKY, DAVID J · 2014 to 2018
$3.4M
Morphine disrupts the regulation of neuronal function mediated by astrocyte exosomesR01DA040390 · NIDA · JOHNS HOPKINS UNIVERSITY · PI HAUGHEY, NORMAN J · 2015 to 2019
$1.8M
NIDA NIH HHS R01 DA037611NIDA NIH HHS R01 DA040390NIMH NIH HHS P01 MH105280NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH104145
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID27080521
PMCPMC5842923

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.