SynthesisJournal of gastrointestinal cancer2016
Systemic Versus Local Therapies for Colorectal Cancer Pulmonary Metastasis: What to Choose and When?
Synthesis in Journal of gastrointestinal cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04160143 (Evaluating the Histologic Effects of Neoadjuvant Stereotactic Body Radiation Therapy), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Histologic Effects of Neoadjuvant Stereotactic Body Radiation Therapy (SBRT) Followed by Pulmonary Metastasectomy-Post SBRT Pulmonary Metastasectomy (PSPM) Trial
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- CT-guided percutaneous radiofrequency ablation for lung metastases from colorectal cancer.International journal of clinical oncology · 2019Trial
- The role of radiotherapy in the management of metastatic rectal cancer: A narrative review on the opportunities for non-operative management and organ preservation.Clinical and translational radiation oncology · 2025Review
- Predicting lung metastasis after radical colorectal cancer surgery: a two center retrospective cohort study and nomogram development.Frontiers in oncology · 2025Article
- A pelvis MR transformer-based deep learning model for predicting lung metastases risk in patients with rectal cancer.Frontiers in oncology · 2025Article
- Review
- Habitat-based radiomics analysis for evaluating immediate response in colorectal cancer lung metastases treated by radiofrequency ablation.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Outcomes and prognostic factors of repeat pulmonary metastasectomy.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Optimizing Treatment Strategy for Oligometastases/Oligo-Recurrence of Colorectal Cancer.Cancers · 2023Review
- Stage IV Colorectal Cancer Management and Treatment.Journal of clinical medicine · 2023Review
- A CT-based radiomics approach to predict immediate response of radiofrequency ablation in colorectal cancer lung metastases.Frontiers in oncology · 2023Article
- The histologic effects of neoadjuvant stereotactic body radiation therapy (SBRT) followed by pulmonary metastasectomy-rationale and protocol design for the Post SBRT Pulmonary Metastasectomy (PSPM) trial.Translational cancer research · 2022Article
- A review of interventional treatments for colorectal lung metastases: is it time for a change in practice?Quantitative imaging in medicine and surgery · 2020Article
- Incidence and prognosis of pulmonary metastasis in colorectal cancer: a population-based study.International journal of colorectal disease · 2020Article
- Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition).Journal of hematology & oncology · 2019Review
- Comparison of stereotactic body radiotherapy versus metastasectomy outcomes in patients with pulmonary metastases.Thoracic cancer · 2018Article
- [Expert Consensus for Thermal Ablation of Primary and Metastatic Lung Tumors (2017 Edition)].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2017Article
- Surgical resection of pulmonary metastases from colorectal cancer: 11 years of experiences.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung is the second most common site of colorectal cancer metastasis. Treatment is based mainly on systemic therapy which has largely evolved lately, but outcome remains relatively poor. The place of locoregional therapies as curative strategies is still debated.
methodA systematic literature review was performed by the authors for systemic therapy, surgery, radiofrequency ablation (RFA), and stereotactic body radiation therapy (SBRT). The highest level of evidence for each strategy was presented. Major findings were addressed in a summarized and clinically relevant manner.
resultsAll reported studies were descriptive non comparative reports except for one retrospective study comparing surgery to SBRT. The highest level of evidence for each therapeutic strategy are presented as follows: three large meta-analyses for surgery as well as seven and three prospective trials for RFA and SBRT, respectively. DISCUSSION: Surgery has the highest level of evidence for cure followed by RFA and SBRT. However, careful patient selection and complete resection of all metastasis are the main principles behind the efficacy of local therapies in the curative setting. Despite encouraging results, randomized trials are still needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.