ArticleReproductive biology and endocrinology : RB&E2016
Aneuploidy analysis in day 7 human blastocysts produced by in vitro fertilization.
Article in Reproductive biology and endocrinology : RB&E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Euploidy rate and reproductive outcomes in embryos biopsied at days 5, 6, 7 and 8 of development: a multicenter study.Journal of assisted reproduction and genetics · 2025Observational
- Effect of Blastocyst Morphology and Developmental Rate on Euploidy and Live Birth Rates in PGT-A Cycles: A Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Trophectoderm Biopsy: Present State of the Art.Genes · 2025Review
- Trisomy 21 and Assisted Reproductive Technologies: A review.JBRA assisted reproduction · 2022Review
- Clinical outcome analysis of frozen-thawed embryo transfer on Day 7.Frontiers in endocrinology · 2022Article
- Heavy metals and metalloids exposure andFrontiers in reproductive health · 2022Review
- Transfer the best and biopsy the rest? Blastocyst euploidy rates differ by morphology and day of biopsy.Archives of gynecology and obstetrics · 2021Article
- Analysis of Biochemical and Clinical Pregnancy Loss Between Frozen-Thawed Embryo Transfer of Blastocysts and Day 3 Cleavage Embryos in Young Women: A Comprehensive Comparison.Frontiers in endocrinology · 2021Article
- PROGNOSTIC VALUE OF BLASTOCYST GRADE AFTER FROZEN EUPLOID EMBRYO TRANSFER IN PATIENTS WITH RECURRENT PREGNANCY LOSS.F&S reports · 2020Article
- Establishment of day 7 blastocyst freezing criteria using blastocyst diameter for single vitrified-warmed blastocyst transfer from live birth outcomes: a single-center, large cohort, retrospectively matched study.Journal of assisted reproduction and genetics · 2020Article
- Is day 7 culture necessary for in vitro fertilization of cryopreserved/warmed human oocytes?Reproductive biology and endocrinology : RB&E · 2020Article
- Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population.Journal of assisted reproduction and genetics · 2019Article
- Earlier day of blastocyst development is predictive of embryonic euploidy across all ages: essential data for physician decision-making and counseling patients.Journal of assisted reproduction and genetics · 2018Article
- Association between growth dynamics, morphological parameters, the chromosomal status of the blastocysts, and clinical outcomes in IVF PGS cycles with single embryo transfer.Journal of assisted reproduction and genetics · 2017Article
- The slow growing embryo and premature progesterone elevation: compounding factors for embryo-endometrial asynchrony.Human reproduction (Oxford, England) · 2017Article
- Number of blastocysts biopsied as a predictive indicator to obtain at least one normal/balanced embryo following preimplantation genetic diagnosis with single nucleotide polymorphism microarray in translocation cases.Journal of assisted reproduction and genetics · 2017Article
- Analysis of a Preimplantation Genetic Test for Aneuploidies in Embryos from Colombian Couples: A Report of Cases.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman embryos produced by in vitro fertilization (IVF) are usually cultured to day 6 after insemination, and good quality of embryos should develop to blastocyst stage at days 5 and 6. However, some embryos develop slowly, thus they may form blastocysts on day 7. Most IVF laboratories culture embryos to day 6 and then discard retarded embryos that do not develop to blastocyst stage. It has been reported that transfer of day 7 blastocysts can yield pregnancy although the rates were very low. In the present study, we evaluated the prevalence of aneuploidy in day 7 human blastocysts and also assessed embryo implantation after transfer of normal euploid blastocysts developed on day 7.
methodsDay 7 blastocysts were biopsied and screened for aneuploidy. Embryo implantation was assessed by transferring of euploid blastocysts.
resultsA total of 1966 blastocysts from 367 IVF cycles were biopsied and screened for aneuploidy. It was found that 81.5 % of the patients had days 5 and 6 blastocysts and 18.5 % (68) patients had blastocysts developed on day 7, including 15.3 % had days 5-7 blastocysts and 3.3 % had only day 7 blastocysts. A total of 151 day 7 blastocysts, which accounted for 7.7 % of total blastocysts, were analyzed. It was found that 36.7 % of the blastocysts were euploid and 63.3 % had abnormal chromosomes, including aneuploidy and euploid with partial chromosome deletion. The aneuploidy rate was also maternal age dependent and was as high as 91.7 % in patients who were ≥40 years old. During the study period, transfer of day 7 euploid blastocysts in 15 patients resulted in 2 healthy live births. CONCLUSION(S): Aneuploidy rates in day 7 human blastocysts produced by IVF are very high. However, good euploid blastocysts have potential to implant and transfer of day 7 euploid blastocysts can result in healthy live birth. It is suggested that day 7 blastocyst culture may be necessary in patients who need aneuploidy screening.
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