Evidence map›Paper›PMID 27080123›Full record

Observational studyArthritis research & therapy2016

Self-reported flares are predictors of radiographic progression in rheumatoid arthritis patients in 28-joint disease activity score remission: a 24-month observational study.

Francesca Ometto, Bernd Raffeiner, Livio Bernardi, Costantino Bostsios, Nicola Veronese, Leonardo Punzi, Andrea Doria

Erratum issuedOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Arthritis research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Evaluation of a multidisciplinary care model to improve quality of life in rheumatoid arthritis: a randomised controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Trial
  2. Article
  3. COVID-19: What Do Rheumatologists Need to Know?Current rheumatology reports · 2021
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
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  10. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Francesca OmettoRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Bernd RaffeinerRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Livio BernardiRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Costantino BostsiosRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Nicola VeroneseDepartment of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Leonardo PunziRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Andrea DoriaRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy. adoria@unipd.it.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease flares are common in rheumatoid arthritis (RA) and are related to structural damage. However, few data on the impact of flares reported by patients on radiographic progression are available. Our aim was to investigate whether overall flares (OF), self-reported flares (SRF) and short flares assessed at the visit (SF) predict radiographic progression in RA patients in DAS28 (28-joint disease activity score) remission.

methodsWe reviewed the records of RA patients included in our database. We considered all patients who had a period of at least 24 months in remission (DAS28 < 2.6), stable biologic and synthetic disease-modifying anti-rheumatic drug treatment, no missing follow-up visits and hands and feet radiographs at the start and at the end of the 24-month follow up. Radiographic progression was considered as an increase in the van der Heijde modified total Sharp score >0. Patients were assessed every 3 months and flares were recorded. We defined SRF as any worsening of the disease reported by patients occurring in the time between visits and SF as an increase in DAS28 ≥ 2.6 or >0.6 from the previous visit assessed by the physician in one isolated visit. The impact of SRF, SF and OF on radiographic progression was assessed through multivariate regression analysis.

resultsOne hundred forty-nine patients were included. The median number (interquartile range) of OF was 1.00/year (0.50; 1.38), of SRF was 0.50/year (0.14; 1.00), and of SF was 0.34/year (0; 0.50). Eighteen patients (12.1 %) experienced a progression of radiographic damage. OF and SRF were significant predictors of radiographic progression: OR 3.27, 95 % CI 1.30, 8.22 and OR 3.63, 95 % CI 1.16, 11.36, respectively.

conclusionsOF and SRF are predictors of structural damage. Flares assessed at the visit, SF, do not impact on radiographic progression as they might underestimate the actual number of flares.

Indexed as

Self ReportAdultAgedAntirheumatic AgentsArthritis, RheumatoidArthrographyDisease ProgressionFemaleHumansMaleMiddle AgedRemission InductionRetrospective StudiesAntirheumatic AgentsBiologic treatmentDAS28 remissionFlaresRadiographic progressionRheumatoid arthritisSelf-reported flares

Identifiers

PMID27080123
PMCPMC4831166
OpenAlexW2336442887

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.