Evidence map›Paper›PMID 27080113›Full record

ArticleThe journal of headache and pain2016

Increased prevalence of depression and anxiety in patients with migraine and interictal photophobia.

Stephanie M Llop, Jonathan E Frandsen, Kathleen B Digre, Bradley J Katz, Alison V Crum, Chong Zhang, Judith E A Warner

Open access · goldAbstract read
In one paragraph

Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Article
  8. Visual Perception in Migraine: A Narrative Review.Vision (Basel, Switzerland) · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Shedding light on photophobia.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Stephanie M LlopDepartment of Ophthalmology, University of Puerto Rico School of Medicine, PO Box 365067, San Juan, Puerto Rico, 00936, USA.
Jonathan E FrandsenDepartment of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah Health Sciences Center, 65 N. Mario Capecchi Drive, Salt Lake City, UT, 84132, USA.
Kathleen B DigreDepartment of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah Health Sciences Center, 65 N. Mario Capecchi Drive, Salt Lake City, UT, 84132, USA.
Bradley J KatzDepartment of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah Health Sciences Center, 65 N. Mario Capecchi Drive, Salt Lake City, UT, 84132, USA.
Alison V CrumDepartment of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah Health Sciences Center, 65 N. Mario Capecchi Drive, Salt Lake City, UT, 84132, USA.
Chong ZhangDivision of Epidemiology, Department of Internal Medicine, University of Utah Health Sciences Center, 30 N 1900 East, Salt Lake City, UT, 84132, USA.
Judith E A WarnerDepartment of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah Health Sciences Center, 65 N. Mario Capecchi Drive, Salt Lake City, UT, 84132, USA. Judith.warner@hsc.utah.edu.
University of Utah · USUniversity of Puerto Rico System · PR

Funding

University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
University of Utah Center for Clinical and Translational Science-UL1UL1TR000105 · NCATS · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2012 to 2013
$5.1M
Short-Term Training: Students in Health Professional SchoolsT35HL007744 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RONDINA, MATTHEW THOMAS, TRISTANI-FIROUZI, MARTIN · 1993 to 2025
$3.1M
NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR001067NCRR NIH HHS UL1 RR025764NHLBI NIH HHS T35 HL007744
6 · The paper itself

Abstract

backgroundMost patients with migraine report photophobia associated with headache; a subset report interictal photophobia. These patients are light sensitive even during headache-free periods. The objective of this case-control study was to assess the prevalence of symptoms of anxiety and depression in migraine patients with and without interictal photophobia.

methodsWe recruited 16 subjects with migraine and interictal photophobia, 16 age- and gender-matched migraine subjects without interictal photophobia, and 16 age- and gender- matched controls. Migraine subjects met International Headache Society classification criteria. Participants completed a photophobia questionnaire, Beck Depression Inventory (BDI-II), and Beck Anxiety Inventory (BAI). Chi-square analyses and two-tailed Wilcoxon rank sum tests were used for the analyses.

resultsSubjects with interictal photophobia had significantly higher scores on the photophobia questionnaire compared to subjects without interictal photophobia. Subjects with interictal photophobia had significantly higher scores on the BDI-II and BAI compared to subjects without interictal photophobia.

conclusionsMigraine patients with interictal photophobia are more likely to manifest symptoms of depression and anxiety compared to migraine patients without interictal photophobia. Care providers should be aware of increased prevalence of these symptoms in this population and consider appropriate referrals. Future research could assess whether treatment of photophobia leads to improvements in symptoms of depression and anxiety in migraine patients.

Indexed as

AnxietyCase-Control StudiesComorbidityDepressionFemaleHumansMaleMiddle AgedMigraine DisordersPhotophobiaPrevalencePsychiatric Status Rating ScalesSeizuresSurveys and QuestionnairesAnxietyDepressionIntrinsically photosensitive retinal ganglion cellsMigrainePhotophobiaSleep disorders

Identifiers

PMID27080113
PMCPMC4831954
OpenAlexW2340714329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.