ArticleNanotoxicology2016
Spermiotoxicity of nickel nanoparticles in the marine invertebrate Ciona intestinalis (ascidians).
Article in Nanotoxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of nTiOToxics · 2026Article
- Promoting Drp1-Mediated Mitochondrial Division in Nickel Nanoparticles-Induced Reproductive Toxicity in GC-2 Cells.Nanomaterials (Basel, Switzerland) · 2025Article
- Ecotoxicological Effects of Environmentally Relevant Concentrations of Nickel Nanoparticles on Aquatic Organisms from Three Trophic Levels: Insights from Oxidative Stress Biomarkers.Journal of xenobiotics · 2025Article
- Morphological Characteristics, Mitochondrial Genome, and Evolutionary Insights Into a New Sea Squirt From the Beibu Gulf.Ecology and evolution · 2025Article
- Women researchers in tunicate biology at the Stazione Zoologica Anton Dohrn in Napoli.Genesis (New York, N.Y. : 2000) · 2023Article
- Immune and Reproductive Biomarkers in Female Sea UrchinsBiomolecules · 2023Article
- Short-Term Thermal Stress Affects Immune Cell Features in the Sea UrchinAnimals : an open access journal from MDPI · 2023Article
- A Molecular Mechanism to Explain the Nickel-Induced Changes in Protamine-like Proteins and Their DNA Binding Affecting Sperm Chromatin inBiomolecules · 2023Article
- Nickel oxide nanoparticles exposure as a risk factor for male infertility: "Frontiers in endocrinology · 2023Article
- Electrophysiology and Fluorescence Spectroscopy Approaches for Evaluating Gamete and Embryo Functionality in Animals and Humans.Biomolecules · 2022Review
- Article
- Exposure of adult sand dollars (Scaphechinus mirabilis) (Agassiz, 1864) to copper oxide nanoparticles induces gamete DNA damage.Environmental science and pollution research international · 2022Article
- Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System.International journal of molecular sciences · 2021Review
- Sperm Motility, Oxidative Status, and Mitochondrial Activity: Exploring Correlation in Different Species.Antioxidants (Basel, Switzerland) · 2021Article
- Effects of Au/TiOEnvironmental science and pollution research international · 2021Article
- Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests.Environmental toxicology and chemistry · 2020Review
- Advance on toxicity of metal nickel nanoparticles.Environmental geochemistry and health · 2020Review
- Study on the damage of sperm induced by nickel nanoparticle exposure.Environmental geochemistry and health · 2020Article
- Investigation of toxic effects of amorphous SiOEnvironmental science and pollution research international · 2019Article
- SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice.Journal of nanobiotechnology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nickel nanoparticles (Ni NPs) are increasingly used in modern industries as catalysts, sensors, and in electronic applications. Due to this large use, their inputs into marine environment have significantly increased; however, the potential ecotoxicological effects in marine environment have so far received little attention. In particular, little is known on the impact of NPs on gamete quality of marine organisms and on the consequences on fertility potential. The present study examines, for the first time, the impact of Ni NPs exposure on sperm quality of the marine invertebrate Ciona intestinalis (ascidian). Several parameters related with sperm status such as plasma membrane lipid peroxidation, mitochondrial membrane potential (MMP), intracellular pH, DNA integrity, and fertilizing ability were assessed as toxicity end points after exposure to different Ni NPs concentrations. Ni NPs generate oxidative stress that in turn induces lipid peroxidation and DNA fragmentation, and alters MMP and sperm morphology. Furthermore, sperm exposure to Ni NPs affects their fertilizing ability and causes developmental anomalies in the offspring. All together, these results reveal a spermiotoxicity of Ni NPs in ascidians suggesting that the application of these NPs should be carefully assessed as to their potential toxic effects on the health of marine organisms that, in turn, may influence the ecological system. This study shows that ascidian sperm represent a suitable and sensitive tool for the investigation of the toxicity of NPs entered into marine environment, for defining the mechanisms of toxic action and for the environmental monitoring purpose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.