Evidence map›Paper›PMID 27079753›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2016

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.

Genevera I Allen, Nicola Amoroso, Catalina Anghel, Venkat Balagurusamy, Christopher J Bare, Derek Beaton, Roberto Bellotti, David A Bennett, Kevin L Boehme, Paul C Boutros and 92 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Bayesian Scalar on Image Regression With Nonignorable Nonresponse.Journal of the American Statistical Association · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

102 authors.

Genevera I AllenDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Nicola AmorosoDipartimento di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Bari, Italy; Sezione di Bari, Istituto Nazionale di Fisica Nucleare, Bari, Italy.
Catalina AnghelOntario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada.
Venkat BalagurusamyIBM Computational Biology Center, IBM Research, NY, USA.
Christopher J BareSage Bionetworks, Seattle, WA, USA.
Derek BeatonSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA.
Roberto BellottiDipartimento di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Bari, Italy; Sezione di Bari, Istituto Nazionale di Fisica Nucleare, Bari, Italy.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Kevin L BoehmeDepartment of Biology, Brigham Young University, Provo, UT, USA.
Paul C BoutrosOntario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada.
Laura CaberlottoThe Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Cristian CaloianOntario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada.
Frederick CampbellDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Elias Chaibub NetoSage Bionetworks, Seattle, WA, USA.
Yu-Chuan ChangGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Beibei ChenQuantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chien-Yu ChenDepartment of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan.
Ting-Ying ChienInnovation Center for Big Data and Digital Convergence, Yuan Ze University, Taoyuan, Taiwan.
Tim ClarkDepartment of Neurology, Massachusetts General Hospital, Cambridge, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Sudeshna DasDepartment of Neurology, Massachusetts General Hospital, Cambridge, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Christos DavatzikosCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Jieyao DengSchool of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China.
Donna DillenbergerIBM Computational Biology Center, IBM Research, NY, USA.
Richard J B DobsonNIHR Biomedical Research Centre for Mental Health, Kings College London, London, UK; Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, Kings College London, London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London WC1E 6BT, UK.
Qilin DongSchool of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China.
Jimit DoshiCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Denise DumaDepartment of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX, USA.
Rosangela ErricoUniversità degli Studi di Genova, Genova, Italy.
Guray ErusCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Evan EverettDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
David W FardoSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
Stephen H FriendSage Bionetworks, Seattle, WA, USA.
Holger FröhlichBonn-Aachen International Center for IT, University of Bonn, Bonn, Germany.
Jessica GanDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Peter St George-HyslopCambridge Institute for Medical Research, University of Cambridge and University of Toronto, Cambridge, CB2, UK.
Satrajit S GhoshMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA.
Enrico GlaabLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Robert C GreenDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Broad Institute and Harvard Medical School, Boston, MA, USA.
Yuanfang GuanDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Ming-Yi HongDepartment of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan.
Chao HuangDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jinseub HwangDepartment of Computer science and Statistics, Daegu University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea.
Joseph IbrahimDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Paolo IngleseDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Anandhi IyappanFraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany.
Qijia JiangDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Yuriko KatsumataDepartment of Biostatistics, University of Kentucky, Lexington, KY, USA.
John S K KauweDepartment of Biology, Brigham Young University, Provo, UT, USA. Electronic address: kauwe@byu.edu.
Arno KleinSage Bionetworks, Seattle, WA, USA. Electronic address: arno@binarybottle.com.
Dehan KongDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Roland KrauseLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Emilie LalondeOntario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada.
Mario LauriaThe Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Eunjee LeeDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xihui LinOntario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada.
Zhandong LiuDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Julie LivingstoneOntario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada.
Benjamin A LogsdonSage Bionetworks, Seattle, WA, USA.
Simon LovestoneDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Tsung-Wei MaQuantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ashutosh MalhotraFraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany.
Lara M MangraviteSage Bionetworks, Seattle, WA, USA. Electronic address: lara.mangravite@sagebase.org.
Taylor J MaxwellComputational Biology Institute, The George Washington University, Ashburn, VA, USA.
Emily MerrillDepartment of Neurology, Massachusetts General Hospital, Cambridge, MA, USA.
John NagorskiDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Aishwarya NamasivayamLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Manjari NarayanDepartment of Statistics and Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Mufassra NazFraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany.
Stephen J NewhouseNIHR Biomedical Research Centre for Mental Health, Kings College London, London, UK; Department of Biostatistics, Kings College London, London, UK.
Thea C NormanSage Bionetworks, Seattle, WA, USA.
Ramil N NurtdinovDepartment of Neuroimmunology, Foundation Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Yen-Jen OyangGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Yudi PawitanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Shengwen PengSchool of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China.
Mette A PetersSage Bionetworks, Seattle, WA, USA. Electronic address: mette.peters@sagebase.org.
Stephen R PiccoloDepartment of Biology, Brigham Young University, Provo, UT, USA.
Paurush PraveenThe Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy; Bonn-Aachen International Center for IT, University of Bonn, Bonn, Germany.
Corrado PriamiThe Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Veronica Y SabelnykovaOntario Institute for Cancer Research, Informatics and Bio-computing Program, MaRS Centre, Toronto, ON, Canada.
Philipp SengerFraunhofer Institute for Algorithms and Scientific Computing (SCAI), Department for Bioinformatics, Schloss Birlinghoven, Sankt Augustin, Germany.
Xia ShenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Andrew SimmonsNIHR Biomedical Research Centre for Mental Health, Kings College London, London, UK.
Aristeidis SotirasCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Gustavo StolovitzkyGenetics and Genomics Sciences Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA; IBM Computational Biology Center, IBM Research, NY, USA.
Sabina TangaroSezione di Bari, Istituto Nazionale di Fisica Nucleare, Bari, Italy.
Andrea TateoDipartimento di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Bari, Italy.
Yi-An TungGenome and systems biology degree program, National Taiwan University, Taipei, Taiwan.
Nicholas J TustisonDepartment of Radiology and Medical Imaging, The University of Virginia, Charlottesville, VA, USA.
Erdem VarolCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
George VradenburgGlobal CEO Initiative on Alzheimer's disease, Washington, DC, USA.
Michael W WeinerRadiology, Medicine, Psychiatry, and Neurology, UCSF, SFVAMC, San Francisco, CA, USA.
Guanghua XiaoQuantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lei XieDepartment of Computer Science, Hunter College, The City University of New York, New York, NY, USA.
Yang XieQuantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jia XuQuantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hojin YangDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xiaowei ZhanQuantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yunyun ZhouQuantitative Biomedical Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Fan ZhuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Hongtu ZhuDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shanfeng ZhuSchool of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China; Centre for Computational Systems Biology, Fudan University, Shanghai, China.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI RAJAN, KUMAR B. · 1991 to 2020
$28.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Pathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6M
Genetic Epidemiology of Cognitive Decline in an Aging Population SampleR01AG030146 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI EVANS, DENIS A · 2007 to 2018
$6.2M
COMPUTATIONAL NEUROANATOMY OF AGING USING SHAPE ANALYSISR01AG014971 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 1999 to 2015
$3.5M
Exploring the Role of the Brain Transcriptome in Cognitive DeclineR01AG036836 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI DE JAGER, PHILIP L · 2011 to 2014
$2.9M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Research Supplements to Promote Diversity in Health-Related ResearchR01AG042611 · NIA · BRIGHAM YOUNG UNIVERSITY · PI KAUWE, JOHN SAI KEONG · 2012 to 2017
$1.5M
CIHRNIA NIH HHS K01 AG030514NIA NIH HHS K25 AG043546NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG014971NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG042611NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046152NIMH NIH HHS R01 MH086633
6 · The paper itself

Abstract

Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance.

Indexed as

Alzheimer DiseaseApolipoproteins EBiomarkersCognition DisordersComputational BiologyDatabases, BibliographicHumansPredictive Value of TestsApolipoproteins EBiomarkersAzheimer's diseaseBig dataBioinformaticsBiomarkersCognitive declineCrowdsourceGeneticsImaging

Identifiers

PMID27079753
PMCPMC5474755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.