ArticleJournal of Alzheimer's disease : JAD2016
Dementia Risk and Protective Factors Differ in the Context of Memory Trajectory Groups.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Stroke and dementia risk: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Pooled it
- Trajectories of Cognitive Change and Their Association with All-Cause Mortality Among Chinese Older Adults: Results from the Chinese Longitudinal Healthy Longevity Survey.Behavioral sciences (Basel, Switzerland) · 2025Article
- Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- A Multimodal Risk Network Predicts Executive Function Trajectories in Non-demented Aging.Frontiers in aging neuroscience · 2021Article
- Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD · 2021Article
- Latent Cognitive Class at Enrollment Predicts Future Cognitive Trajectories of Decline in a Community Sample of Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Latent Profile Analysis of Cognition in a Non-Demented Diverse Cohort: A Focus on Modifiable Cardiovascular and Lifestyle Factors.Journal of Alzheimer's disease : JAD · 2021Article
- What does (low) education mean in terms of dementia risk? A systematic review and meta-analysis highlighting inconsistency in measuring and operationalising education.SSM - population health · 2020Review
- Distinct Cognitive Trajectories in Late Life and Associated Predictors and Outcomes: A Systematic Review.Journal of Alzheimer's disease reports · 2020Review
- Age of Migration and Cognitive Function Among Older Latinos in the United States.Journal of Alzheimer's disease : JAD · 2020Article
- Population-Based Approaches to Dementia Prevention.Journal of Alzheimer's disease : JAD · 2019Article
- Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI.PloS one · 2019Article
- Modifiable Risk Factors Discriminate Memory Trajectories in Non-Demented Aging: Precision Factors and Targets for Promoting Healthier Brain Aging and Preventing Dementia.Journal of Alzheimer's disease : JAD · 2019Article
- Class-Specific Incidence of All-Cause Dementia and Alzheimer's Disease: A Latent Class Approach.Journal of Alzheimer's disease : JAD · 2018Article
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Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious research has identified multiple risk and protective factors for late onset Alzheimer's disease (LOAD). However, it is not known whether these risk and protective factors differ for individuals who are cognitively stable versus those already experiencing declines.
objectiveThis study examined how dementia risk factors differ across subgroups of older adults defined by memory trajectory. This line of research may lead to more individualized risk profiles.
methodsRisk factors for incident LOAD were compared across previously-validated groups of older adults exhibiting different memory trajectories ("Stable-High," "Stable-Low," "Decliner," "Rapid Decliner") using stratified Cox regressions. Participants included 2,593 racially/ethnically diverse older adults (mean age of 76 at study entry) in the Washington Heights-Inwood Columbia Aging Project.
resultsPredictors of incident dementia differed across trajectory groups: older age only incurred independent risk in stable groups, education did not incur independent protection in the rapidly declining group, depression only incurred independent risk in the stable-low group, stroke incurred independent risk in the two extreme groups, and APOE-ɛ4 only incurred independent risk in the rapidly declining group.
conclusionThe finding that different risk factors for LOAD were associated with specific memory trajectories may reflect the existence of resilience or vulnerability factors that modify the individual influences of risk/protective factors. This study highlights the utility of considering interactions between dementia risk factors and a patient's unique cognitive history.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.