Observational studyJournal of Alzheimer's disease : JAD2016
Describing the Sequence of Cognitive Decline in Alzheimer's Disease Patients: Results from an Observational Study.
Observational study in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neutrophil to lymphocyte ratio in Alzheimer's disease: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations.Parkinsonism & related disorders · 2019Trial
- Effectiveness of nonclinic-based dual-task training on physical and cognitive functions and activities of daily living in older adults with cognitive decline: A systematic review and meta-analysis.PLOS digital health · 2026Article
- Effects on cognition of regional astrogliosis assessed byResearch square · 2026Article
- Longitudinal relations between sleep quality, psychological distress, and cognitive function among rural older adults: a cross-lagged network analysis.Psychological medicine · 2026Article
- Resolving Heterogeneity in the Diagnosis of Alzheimer's Disease and its Progression Using Multimodal Data.Journal of molecular neuroscience : MN · 2026Article
- The role of microbiota modulation in preventing Alzheimer's disease- a review.Pharmacological reports : PR · 2025Review
- Decreased quantitative transport mapping velocity in the middle cerebral artery-supplied temporal lobe in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Inflammation in Older Poles with Localized and Widespread Chronic Pain-Results from a Population-Based PolSenior Study.Journal of clinical medicine · 2024Article
- Exploring the Role of Reactive Oxygen Species in the Pathogenesis and Pathophysiology of Alzheimer's and Parkinson's Disease and the Efficacy of Antioxidant Treatment.Antioxidants (Basel, Switzerland) · 2024Review
- Alzheimer's disease: a review on the current trends of the effective diagnosis and therapeutics.Frontiers in aging neuroscience · 2024Review
- Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease.Molecular brain · 2023Article
- Serum brain-derived neurotrophic factor levels as a predictor for Alzheimer disease progression.Journal of the Chinese Medical Association : JCMA · 2023Observational
- Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Using artificial intelligence to learn optimal regimen plan for Alzheimer's disease.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Determinants of Attitude to a Humanoid Social Robot in Care for Older Adults: A Post-Interaction Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Using Artificial Intelligence to Learn Optimal Regimen Plan for Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2023Article
- The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials.Alzheimer's research & therapy · 2023Article
- Heterogeneity of Alzheimer's disease identified by neuropsychological test profiling.PloS one · 2023Article
- The Patient Voice: Exploring Treatment Preferences in Participants with Mild Cognitive Concerns to Inform Regulatory Decision Making.The patient · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImproved understanding of the pattern of cognitive decline in Alzheimer's disease (AD) would be useful to assist primary care physicians in explaining AD progression to patients and caregivers.
objectiveTo identify the sequence in which cognitive abilities decline in community-dwelling patients with AD.
methodsBaseline data were analyzed from 1,495 patients diagnosed with probable AD and a Mini-Mental State Examination (MMSE) score ≤ 26 enrolled in the 18-month observational GERAS study. Proportional odds logistic regression models were applied to model MMSE subscores (orientation, registration, attention and concentration, recall, language, and drawing) and the corresponding subscores of the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), using MMSE total score as the index of disease progression. Probabilities of impairment start and full impairment were estimated at each MMSE total score level.
resultsFrom the estimated probabilities for each MMSE subscore as a function of the MMSE total score, the first aspect of cognition to start being impaired was recall, followed by orientation in time, attention and concentration, orientation in place, language, drawing, and registration. For full impairment in subscores, the sequence was recall, drawing, attention and concentration, orientation in time, orientation in place, registration, and language. The sequence of cognitive decline for the corresponding ADAS-cog subscores was remarkably consistent with this pattern.
conclusionThe sequence of cognitive decline in AD can be visualized in an animation using probability estimates for key aspects of cognition. This might be useful for clinicians to set expectations on disease progression for patients and caregivers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.