ArticleBMC surgery2016
Factors affecting number of lymph nodes harvested and the impact of examining a minimum of 12 lymph nodes in stage I-III colorectal cancer patients: a retrospective single institution cohort study of 1167 consecutive patients.
Article in BMC surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pooled it
- Allocating colorectal cancer patients to different risk categories by using a five-biomarker mRNA combination in lymph node analysis.PloS one · 2020Trial
- Prognostic value of number of harvested lymph nodes in Stage III colorectal cancer patients.Surgery today · 2026Article
- Optimizing lymph node harvest in laparoscopic colorectal cancer: predictors and station-specific lymph node submission solutions.Annals of coloproctology · 2026Article
- Colorectal lymph node harvest in cancer surgery, adequacy and treatment implication: a 5-year retrospective analysis from a tertiary hospital in Ethiopia.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- A predictive nomogram for assessing the likelihood of retrieving 12 lymph nodes after rectal cancer surgery: a single-center study.Frontiers in oncology · 2025Article
- Article
- Acetone compression improves lymph node yield and metastasis detection in colorectal cancer.Clinical & experimental metastasis · 2024Article
- LGR6 is a prognostic biomarker for less differentiated tumors in lymph nodes of colon cancer patients.Frontiers in oncology · 2024Article
- Lymph node harvesting after laparoscopic complete mesocolic excision colectomy in colon cancer with practical application of glacial acid, absolute ethanol, water, and formaldehyde solution: A prospective cohort study.SAGE open medicine · 2024Article
- Retrospective Cohort Analysis of the Effect of Age on Lymph Node Harvest, Positivity, and Ratio in Colorectal Cancer.Cancers · 2022Article
- Observational
- Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version.Journal of the anus, rectum and colon · 2022Review
- Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?Annals of coloproctology · 2021Review
- Nomograms to predict cancer-specific mortality in colon adenocarcinoma with different types of villous architecture.International journal of colorectal disease · 2021Article
- Surgical outcomes according to the type of monopolar electrocautery device used in laparoscopic surgery for right colon cancer: a comparison of endo-hook versus endo-shears.Surgical endoscopy · 2020Article
- Tumor sidedness influences prognostic impact of lymph node metastasis in colon cancer patients undergoing curative surgery.Scientific reports · 2019Article
- Role of lymph node yield and lymph node ratio in predicting outcomes in non-metastatic colorectal cancer.BJS open · 2019Observational
- Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study.Journal of Cancer · 2018Article
- An increased number of negative lymph nodes is associated with a higher immune response and longer survival in colon cancer patients.Cancer management and research · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo identify factors affecting the harvest of lymph nodes (LNs) and to investigate the association between examining a minimum of 12 LNs and clinical outcomes in stage I-III colorectal cancer (CRC) patients.
methodsThe clinicopathologic features and the number of examined LNs for 1167 stage I-III CRC patients were analyzed to identify factors affecting the number of LNs harvested and the correlations between clinical outcomes and high harvests (≧12 LNs) and low harvests (<12 LNs).
resultsA multivariate analysis showed that age (P = 0.007), tumor size (P = 0.030), and higher T stage (P = 0.001) were independent factors affecting the examinations of LNs in colon cancer and that tumor size (P = 0.015) was the only independent factor in rectal cancer. Patients with low harvests had poorer overall survival with stage II and stage III CRC (stage II: P < 0.0001; III: P = 0.001) and poorer disease-free survival for stages I-III (stage I: P = 0.023; II: P < 0.0001; III: P = 0.001).
conclusionsThe factors influencing nodal harvest are multifactorial, and an adequate number of examined LNs (≧12) is associated with a survival benefit. Removal of at least 12 LNs will determine the lymph node status reliably.
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Registered trials
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