ArticleTechnology in cancer research & treatment2017
Histological and Mathematical Analysis of the Irreversibly Electroporated Liver Tissue.
Article in Technology in cancer research & treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Two-Tier Power and Energy Thresholds Governing Discharge Plasma-Induced Cell Death During Molecular and Gene Delivery.International journal of molecular sciences · 2026Article
- Article
- Evaluation of electroporated area using 2,3,5-triphenyltetrazolium chloride in a potato model.Scientific reports · 2021Article
- Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate.Scientific reports · 2021Article
- Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy.Cancers · 2020Article
- Characterization of irreversible electroporation on the stomach: A feasibility study in rats.Scientific reports · 2019Article
- Incorporation of Reversible Electroporation Into Electrolysis Accelerates Apoptosis for Rat Liver Tissue.Technology in cancer research & treatmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irreversible electroporation has clinically been used to treat various types of cancer. A plan on how to apply irreversible electroporation before practicing is very important to increase the ablation area and reduce the side effects. Several electrical models have been developed to predict the ablation area with applied electric energy. In this experiment, the static relationship between applied electric energy and ablated area was mathematically and experimentally investigated at 10 hours after applying irreversible electroporation. We performed the irreversible electroporation on the liver tissue of Sprague Dawley rats (male, 8 weeks, weighing 250-350 g). The ablated area was measured based on histological analysis and compared with the mathematical calculation from the electric energy, assuming that the tissue is homogeneous. The ablated area increased with the increase in applied electric energy. The numerically calculated contour lines of electric energy density overlapped well with the apoptotic area induced by the irreversible electroporation. The overlapped area clearly showed that the destructive threshold of apoptosis between electrodes is electric energy density level of 5.9 × 10
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Registered trials
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