ArticlePloS one2016
Serum Uric Acid Is Positively Associated with Handgrip Strength among Japanese Community-Dwelling Elderly Women.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- Fatty Acid Profile and Antioxidant Status Fingerprint in Sarcopenic Elderly Patients: Role of Diet and Exercise.Nutrients · 2019Trial
- Inverted U-Shaped Association Between Serum Uric Acid and Handgrip Strength in Chinese Community-Dwelling Adults: A Repeated-Measures Cohort Study.Biomedicines · 2026Article
- Association between serum uric acid and muscle function in underweight young women: An exploratory cross-sectional study.PloS one · 2026Article
- Temporal relationship between serum uric acid and muscle strength: a cross-sectional and longitudinal study of middle-aged and older adults.Scientific reports · 2025Article
- Obesity paradox: association between lipid metabolism indices and skeletal muscle mass in older adults: the mediating role of uric acid.Acta diabetologica · 2025Article
- The ratio of serum uric acid to high-density lipoprotein cholesterol as a predictor for frailty prevalence and mortality in the elderly U.S. adults.Lipids in health and disease · 2025Article
- Article
- Skeletal muscle mass and quality in gout patients versus non-gout controls: A computed tomography imaging study.Joint bone spine · 2024Article
- Article
- Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study.BMC public health · 2024Article
- The correlations of serum uric acid with lean mass, fat mass and grip strength in adolescents aged 12-19 years.Frontiers in endocrinology · 2024Article
- Exploring quantitative traits-associated copy number deletions through reanalysis of UK10K consortium whole genome sequencing cohorts.BMC genomics · 2023Article
- Article
- Interactive effect of serum uric acid and handgrip strength on all-cause mortality among Japanese community-dwelling people.Metabolism open · 2023Article
- Factors Influencing Sarcopenic Changes in YUBI-WAKKA Finger-Ring Test Results After One Year: A Retrospective Observational Study.Journal of clinical medicine research · 2023Article
- Causality between urate levels with sarcopenia-related traits: a bi-directional Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Uric Acid in Parkinson's Disease: What Is the Connection?Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression.Diseases (Basel, Switzerland) · 2022Review
- Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study.BMC geriatrics · 2022Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum uric acid (UA) has strong anti-oxidant properties. Muscle strength and mass decrease with age, and recently, this decrease has been defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether serum UA is associated with handgrip strength (HGS), which is a useful indicator of sarcopenia, among Japanese community-dwelling elderly persons. The present study included 602 men aged 72 ± 7 years and 847 women aged 71 ± 6 years from a rural village. We examined the cross-sectional relationship between serum UA and HGS. In both genders, HGS increased significantly with increased serum UA levels. A multiple linear regression analysis using HGS as an objective variable and various confounding factors as explanatory variables showed that in men age, drinking status, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and estimated glomerular filtration ratio (eGFRCKDEPI) were independently and significantly associated with HGS, and in women, serum UA as well as age, body mass index, drinking status, diastolic blood pressure, and eGFRCKDEPI were independently and significantly associated with HGS. In women, age and multivariate-adjusted HGS were significantly higher in the Quartile-3 (4.8-5.4 mg/dL) and Quartile-4 groups (5.5-9.3 mg/dL) of serum UA than in the lower groups (0.7-4.7 mg/dL). These results suggest that serum UA may have a protective role in aging-associated decline in muscle strength in community-dwelling elderly women.
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