Evidence map›Paper›PMID 27078615›Full record

ArticleEye & contact lens2017

Altered Bulbar Conjunctival Microcirculation in Response to Contact Lens Wear.

Wan Chen, Zhe Xu, Hong Jiang, Jin Zhou, Liang Wang, Jianhua Wang

Abstract read
In one paragraph

Article in Eye & contact lens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Evaluation of CelligentDiagnostics (Basel, Switzerland) · 2023
    Article
  3. Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. A review of functional slit lamp biomicroscopy.Eye and vision (London, England) · 2019
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wan ChenDepartment of Ophthalmology (W.C.), Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Ophthalmology (W.C., Z.X., H.J., J.Z., J.W.), Bascom Palmer Eye Institute, University of Miami, Miami, FL; School of Ophthalmology and Optometry (Z.X.), Wenzhou Medical College, Wenzhou, Zhejiang, China; Department of Neurology (H.J.), University of Miami, Miami, FL; Department of Ophthalmology (J.Z.), Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China; and Krieger School of Arts and Sciences (L.W.), Johns Hopkins University, Baltimore, MA.
Zhe Xu
Hong Jiang
Jin Zhou
Liang Wang
Jianhua Wang

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
NEI NIH HHS P30 EY014801
6 · The paper itself

Abstract

purposeThis study was conducted to determine blood flow velocities and corresponding vessel diameters to characterize the response of the bulbar conjunctival microvasculature to contact lens wear.

methodsA functional slit-lamp biomicroscope (FSLB), an adapted traditional slitlamp, was used to image the temporal bulbar conjunctiva of 22 healthy subjects before and after 6 hr of contact lens wear. All of the measurable venules on the conjunctiva were processed to yield vessel diameters and blood flow velocities.

resultsThe average blood flow velocity increased from 0.51±0.20 to 0.65±0.22 mm/sec (P<0.001) after 6 hr of lens wear. The blood flow velocity distribution showed a velocity increase that correlated with the vessel diameter increase from the baseline (r=0.826, P<0.05). This pattern maintained a similar trend after 6 hr of lens wear (r=0.925, P<0.05), and increased velocities were found across all of the vessel diameter ranges (P<0.001).

conclusionsBlood flow velocity increases across all of the vessel diameter ranges in response to contact lens wear. Functional slitlamp biomicroscope is capable of characterizing the bulbar microvascular response to contact lens wear.

Indexed as

AdultBlood Flow VelocityConjunctivaContact LensesFemaleHumansImage Processing, Computer-AssistedMaleMicrocirculationMicrovesselsSlit LampVenules

Identifiers

PMID27078615
PMCPMC5063651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.