ArticleInternational journal of occupational and environmental health2016
Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice.
Article in International journal of occupational and environmental health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Artificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose-Response Meta-Analysis of Prospective Studies.Nutrients · 2022Pooled it
- Urinary Concentrations of Non-Nutritive Sweeteners and Breast Cancer: A Case-Cohort Analysis of the Moli-sani Study.Nutrients · 2026Article
- Mutual Influence of Sucralose and Bisphenol A on Biological and Neurobehavioral Action inInternational journal of molecular sciences · 2026Article
- Re-evaluation of sucralose (E 955) as a food additive and evaluation of a new application on extension of use of sucralose (E 955) in fine bakery wares.EFSA journal. European Food Safety Authority · 2026Article
- Labeled ingredient composition and literature-reported hazard signals in children's toothpastes available through selected UAE retail sources.Frontiers in oral health · 2026Article
- Lack of Genotoxic and Carcinogenic Potential for Nonsugar Sweeteners: A Review of Animal and Mechanistic Evidence.Advances in nutrition (Bethesda, Md.) · 2025Review
- Biological and Behavioral Responses ofInternational journal of molecular sciences · 2025Article
- Review
- Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners.Nutrients · 2025Review
- Formation of Chlorinated Carbohydrate Degradation Products and Amino Acids during Heating of Sucralose in Model Systems and Food.Journal of agricultural and food chemistry · 2024Article
- Sucralose Influences the Productive Performance, Carcass Traits, Blood Components, and Gut Microflora Using 16S rRNA Sequencing of Growing APRI-Line Rabbits.Animals : an open access journal from MDPI · 2024Article
- Sucralose: From Sweet Success to Metabolic Controversies-Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener.Life (Basel, Switzerland) · 2024Review
- Unveiling the profound influence of sucralose on metabolism and its role in shaping obesity trends.Frontiers in nutrition · 2024Review
- Plant-based diets for CKD patients: fascinating, trendy, but feasible? A green nephrology perspective.Clinical kidney journal · 2023Review
- Article
- Antibiotic treatment targeting gram negative bacteria prevents neratinib-induced diarrhea in rats.Neoplasia (New York, N.Y.) · 2022Article
- Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.PLoS medicine · 2022Article
- Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3.Frontiers in nutrition · 2022Article
- Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort.Scientific reports · 2021Article
- Inhibitory Effects of Artificial Sweeteners on Bacterial Quorum Sensing.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSucralose is an organochlorine artificial sweetener approximately 600 times sweeter than sucrose and used in over 4,500 products. Long-term carcinogenicity bioassays on rats and mice conducted on behalf of the manufacturer have failed to show the evidence of carcinogenic effects.
objectiveThe aim of this study was to evaluate the carcinogenic effect of sucralose in mice, using a sensitive experimental design.
methodsFive groups of male (total n = 457) and five groups female (total n = 396) Swiss mice were treated from 12 days of gestation through the lifespan with sucralose in their feed at concentrations of 0, 500, 2,000, 8,000, and 16,000 ppm.
resultsWe found a significant dose-related increased incidence of males bearing malignant tumors (p < 0.05) and a significant dose-related increased incidence (p < 0.01) of hematopoietic neoplasias in males, in particular at the dose levels of 2,000 ppm (p < 0.01) and 16,000 ppm (p < 0.01).
conclusionsThese findings do not support previous data that sucralose is biologically inert. More studies are necessary to show the safety of sucralose, including new and more adequate carcinogenic bioassay on rats. Considering that millions of people are likely exposed, follow-up studies are urgent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.