ArticlePloS one2016
Development of a Short Version of MSQOL-54 Using Factor Analysis and Item Response Theory.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychometrics, diagnostics and usability of Italian tools assessing behavioural and functional outcomes in neurological, geriatric and psychiatric disorders: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Effects of Transcutaneous Spinal Direct Current Stimulation on Cognitive and Psychological Outcomes in Multiple Sclerosis: A Preliminary Case Series.Biomedicines · 2026Article
- Exploring the Psychometric Properties of the Spanish Version of the Life Orientation Test-Revised Among Multiple Sclerosis Patients: Insights into Optimism.Journal of clinical psychology in medical settings · 2025Article
- Perceived health- related quality of life in persons with multiple sclerosis with and without a vascular comorbidity.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Validation of Persian Multiple Sclerosis quality of life-29 (P-MSQOL-29) questionnaire.Acta neurologica Belgica · 2023Article
- Effect of patient-centered and family-centered self-care education program on the quality of life of patients with multiple sclerosis: a quasi-experimental study.BMC nursing · 2023Article
- Semi-automated Rasch analysis with differential item functioning.Behavior research methods · 2023Article
- A composite measure for patient-reported outcomes in orthopedic care: design principles and validity checks.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Coping Strategies and Their Impact on Quality of Life and Physical Disability of People with Multiple Sclerosis.Journal of clinical medicine · 2021Article
- Viability of a MSQOL-54 general health-related quality of life score using bifactor model.Health and quality of life outcomes · 2021Article
- Semi-automated Rasch analysis using in-plus-out-of-questionnaire log likelihood.The British journal of mathematical and statistical psychology · 2021Article
- Social Cognition in Multiple Sclerosis: A 3-Year Follow-Up MRI and Behavioral Study.Diagnostics (Basel, Switzerland) · 2021Article
- Development and validation of the Rapid Positive Mental Health Instrument (R-PMHI) for measuring mental health outcomes in the population.BMC public health · 2020Article
- Assessing measurement invariance of MSQOL-54 across Italian and English versions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Multiple sclerosis.Nature reviews. Disease primers · 2018Review
- Validation of The Slovenian Version of Multiple Sclerosis Quality of Life (MSQOL-54) Instrument.Zdravstveno varstvo · 2017Article
- Health-Related Quality of Life in Patients with Multiple Sclerosis: Impact of Disease-Modifying Drugs.CNS drugs · 2017Review
- AI-based predictive biomarkers for chronic neurological diseases: the rAIdD prospective, multicenter, observational study protocol.Frontiers in neurologyArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Multiple Sclerosis Quality of Life-54 (MSQOL-54, 52 items grouped in 12 subscales plus two single items) is the most used MS specific health related quality of life inventory.
objectiveTo develop a shortened version of the MSQOL-54.
methodsMSQOL-54 dimensionality and metric properties were investigated by confirmatory factor analysis (CFA) and Rasch modelling (Partial Credit Model, PCM) on MSQOL-54s completed by 473 MS patients. Their mean age was 41 years, 65% were women, and median Expanded Disability Status Scale (EDSS) score was 2.0 (range 0-9.5). Differential item functioning (DIF) was evaluated for gender, age and EDSS. Dimensionality of the resulting short version was assessed by exploratory factor analysis (EFA) and CFA. Cognitive debriefing of the short instrument (vs. the original) was then performed on 12 MS patients.
resultsCFA of MSQOL-54 subscales showed that the data fitted the overall model well. Two subscales (Role Limitations--Physical, Role Limitations--Emotional) did not fit the PCM, and were removed; two other subscales (Health Perceptions, Social Function) did not fit the model, but were retained as single items. Sexual Satisfaction (single-item subscale) was also removed. The resulting MSQOL-29 consisted of 25 items grouped in 7 subscales, plus 4 single items. PCM fit statistics were within the acceptability range for all MSQOL-29 items except one which had significant DIF by age. EFA and CFA indicated adequate fit to the original two-factor (Physical and Mental Health Composites) hypothesis. Cognitive debriefing confirmed that MSQOL-29 was acceptable and had lost no key items.
conclusionsThe proposed MSQOL-29 is 50% shorter than MSQOL-54, yet preserves key quality of life dimensions. Prospective validation on a large, independent MS patient sample is ongoing.
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