ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration
Single and modeled multifrequency electrical impedance myography parameters and their relationship to force production in the ALS SOD1G93A mouse.
Article in Amyotrophic lateral sclerosis & frontotemporal degeneration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
- Surface electrical impedance myography detects disease in an adult-onset SOD1-G93A zebrafish model of amyotrophic lateral sclerosis.Scientific reports · 2025Article
- Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish.Scientific reports · 2023Article
- Electrical impedance myography combined with quantitative assessment techniques in paretic muscle of stroke survivors: Insights and challenges.Frontiers in aging neuroscience · 2023Article
- Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents.Journal of visualized experiments : JoVE · 2022Article
- Antisense oligonucleotide and adjuvant exercise therapy reverse fatigue in old mice with myotonic dystrophy.Molecular therapy. Nucleic acids · 2021Article
- Using Electrical Impedance Myography as a Biomarker of Muscle Deconditioning in Rats Exposed to Micro- and Partial-Gravity Analogs.Frontiers in physiology · 2020Article
- Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice.Muscle & nerve · 2019Article
- Estimating Myofiber Size With Electrical Impedance Myography: a Study In Amyotrophic Lateral Sclerosis MICE.Muscle & nerve · 2018Article
- Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018Article
- Electrical impedance myography as a biomarker of myostatin inhibition with ActRIIB-mFc: a study in wild-type mice.Future science OA · 2018Article
- Predicting myofiber size with electrical impedance myography: A study in immature mice.Muscle & nerve · 2018Article
- Electrical Impedance Myography and Its Applications in Neuromuscular Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Article
- Non-invasive evaluation of muscle disease in the canine model of Duchenne muscular dystrophy by electrical impedance myography.PloS one · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe relationship between muscle force production in ALS SOD1G93A mice and single and modeled multifrequency electrical impedance myography (EIM) parameters is unknown. We evaluated the relationship between multifrequency EIM data and paw grip and in situ force measurements, as well to standard measures including body weight and compound motor action potential (CMAP) amplitude.
methodsTwenty-nine SOD1 G93A mice aged 13-18 weeks (approximately 4-5 per week) and a group of similarly aged wild-type mice (N = 7) were studied with single and multifrequency EIM, CMAP, front and hind-limb paw grip measures, and in situ force measurements of the gastrocnemius.
resultsSignificant differences among WT, presymptomatic, and symptomatic ALS animals were identified for all standard measures and single 50 kHz frequency EIM parameters. Of the modeled multifrequency measures, the center frequency, fc , an index of cell size, showed the strongest relationship to force output. The two other multifrequency parameters corresponding to cell size distribution and cell density showed consistent although mostly non-significant differences.
conclusionReductions in force are reflected in single 50 kHz impedance values and in the fc. These data support the construct validity of EIM as an assessment tool of muscle dysfunction in diseases associated with motor neuron loss.
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