Evidence map›Paper›PMID 27077849›Full record

ReviewInternational journal of molecular sciences2016

Campylobacter jejuni Fatal Sepsis in a Patient with Non-Hodgkin's Lymphoma: Case Report and Literature Review of a Difficult Diagnosis.

Maria Teresa Gallo, Enea Gino Di Domenico, Luigi Toma, Francesco Marchesi, Lorella Pelagalli, Nicola Manghisi, Fiorentina Ascenzioni, Grazia Prignano, Andrea Mengarelli, Fabrizio Ensoli

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Campylobacter jejuni bacteremia in a neutropenic child with B-Cell acute lymphoblastic leukemia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Infectious Diseases: Pathophysiology, Diagnostics and Prevention.International journal of molecular sciences · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Maria Teresa GalloDepartment of Clinical Pathology and Microbiology, San Gallicano Institute, IRCCS, Rome 00144, Italy. gallo@ifo.it.
Enea Gino Di DomenicoDepartment of Clinical Pathology and Microbiology, San Gallicano Institute, IRCCS, Rome 00144, Italy. e.didomenico@ifo.it.
Luigi TomaDepartment of Infectious Disease, San Gallicano Institute, IRCCS, Rome 00144, Italy. toma@ifo.it.
Francesco MarchesiDepartment of Hematology, Regina Elena National Cancer Institute IRCCS, Rome 00144, Italy. marchesi.francesco@tiscali.it.
Lorella PelagalliIntensive Care Medicine, Regina Elena National Cancer Institute IRCCS, Rome 00144, Italy. pelagalli@ifo.it.
Nicola ManghisiDepartment of Clinical Pathology and Microbiology, San Gallicano Institute, IRCCS, Rome 00144, Italy. n.manghisi@gmail.com.
Fiorentina AscenzioniDepartment of Biology and Biotechnology "Charles Darwin", University of Rome Sapienza, Rome 00185, Italy. fiorentina.ascenzioni@uniroma1.it.
Grazia PrignanoDepartment of Clinical Pathology and Microbiology, San Gallicano Institute, IRCCS, Rome 00144, Italy. prignano@ifo.it.
Andrea MengarelliDepartment of Hematology, Regina Elena National Cancer Institute IRCCS, Rome 00144, Italy. mengarelli@ifo.it.
Fabrizio EnsoliDepartment of Clinical Pathology and Microbiology, San Gallicano Institute, IRCCS, Rome 00144, Italy. ensoli@ifo.it.
San Gallicano Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Campylobacter jejuni (C. jejuni) bacteremia is difficult to diagnose in individuals with hematological disorders undergoing chemotherapy. The cause can be attributed to the rarity of this infection, to the variable clinical presentation, and to the partial overlapping symptoms underlying the disease. Here, we report a case of a fatal sepsis caused by C. jejuni in a 76-year-old Caucasian man with non-Hodgkin's lymphoma. After chemotherapeutic treatment, the patient experienced fever associated with severe neutropenia and thrombocytopenia without hemodynamic instability, abdominal pain, and diarrhea. The slow growth of C. jejuni in the blood culture systems and the difficulty in identifying it with conventional biochemical phenotyping methods contributed to the delay of administering a targeted antimicrobial treatment, leading to a fatal outcome. Early recognition and timely intervention are critical for the successful management of C. jejuni infection. Symptoms may be difficult to recognize in immunocompromised patients undergoing chemotherapy. Thus, it is important to increase physician awareness regarding the clinical manifestations of C. jejuni to improve therapeutic efficacy. Moreover, the use of more aggressive empirical antimicrobial treatments with aminoglycosides and/or carbapenems should be considered in immunosuppressed patients, in comparison to those currently indicated in the guidelines for cancer-related infections supporting the use of cephalosporins as monotherapy.

Indexed as

AgedAnti-Infective AgentsCampylobacter InfectionsCampylobacter jejuniEarly DiagnosisFatal OutcomeHumansImmunocompromised HostLymphoma, Non-HodgkinMaleSepsisTime-to-TreatmentAnti-Infective AgentsCampylobacter jejunichemotherapynon-Hodgkin’s lymphomaskin lesion

Identifiers

PMID27077849
PMCPMC4849000
OpenAlexW2340029238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.