ArticleCell death & disease2016
TAK1 regulates Paneth cell integrity partly through blocking necroptosis.
Article in Cell death & disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Reactive oxygen species stimulate Paneth cell plasticity and diminish antimicrobial function.The EMBO journal · 2026Article
- PARVB deficiency alleviates cisplatin-induced tubular injury by inhibiting TAK1 signaling.Cellular and molecular life sciences : CMLS · 2024Article
- Intercalated cell function, kidney innate immunity, and urinary tract infections.Pflugers Archiv : European journal of physiology · 2024Review
- From birth to death: The hardworking life of Paneth cell in the small intestine.Frontiers in immunology · 2023Review
- MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure.Journal of cellular biochemistry · 2022Article
- E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.Nature cell biology · 2021Article
- TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cell death in the gut epithelium and implications for chronic inflammation.Nature reviews. Gastroenterology & hepatology · 2020Review
- An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.Blood · 2020Article
- TAK1 regulates endothelial cell necroptosis and tumor metastasis.Cell death and differentiation · 2019Article
- Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.The Journal of experimental medicine · 2017Article
- LiCl Treatment Induces Programmed Cell Death of Schwannoma Cells through AKT- and MTOR-Mediated Necroptosis.Neurochemical research · 2017Article
- Activation of TGF-Physiological reports · 2017Article
- TAK1 regulates resident macrophages by protecting lysosomal integrity.Cell death & disease · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Paneth cells reside at the base of crypts of the small intestine and secrete antimicrobial factors to control gut microbiota. Paneth cell loss is observed in the chronically inflamed intestine, which is often associated with increased reactive oxygen species (ROS). However, the relationship between Paneth cell loss and ROS is not yet clear. Intestinal epithelial-specific deletion of a protein kinase Tak1 depletes Paneth cells and highly upregulates ROS in the mouse model. We found that depletion of gut bacteria or myeloid differentiation factor 88 (Myd88), a mediator of bacteria-derived cell signaling, reduced ROS but did not block Paneth cell loss, suggesting that gut bacteria are the cause of ROS accumulation but bacteria-induced ROS are not the cause of Paneth cell loss. In contrast, deletion of the necroptotic cell death signaling intermediate, receptor-interacting protein kinase 3 (Ripk3), partially blocked Paneth cell loss. Thus, Tak1 deletion causes Paneth cell loss in part through necroptotic cell death. These results suggest that TAK1 participates in intestinal integrity through separately modulating bacteria-derived ROS and RIPK3-dependent Paneth cell loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.