Evidence map›Paper›PMID 27077649›Full record

ArticlePloS one2016

Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease.

D Tomas, D Stanic, H K Chua, K White, W C Boon, M Horne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

D TomasFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, 3010.
D StanicFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, 3010.
H K ChuaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, 3010.
K WhiteFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, 3010.
W C BoonFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, 3010.
M HorneFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, 3010.
Florey Institute of Neuroscience and Mental Health · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter. In this study we have examined the proposition that reinstating Dopamine Transporter expression in the striatum would reduce dyskinesia. We transplanted c17.2 cells that stably expressed the Dopamine Transporter into dyskinetic rats. There was a reduction in dyskinesia in rats that received grafts expressing the Dopamine Transporter. Strategies designed to increase Dopamine Transporter in the striatum may be useful in treating the dyskinesia associated with human Parkinson's Disease.

Indexed as

AnimalsBehavior, AnimalBrainCell- and Tissue-Based TherapyCell LineDisease Models, AnimalDopamineDopamine Plasma Membrane Transport ProteinsDyskinesia, Drug-InducedLevodopaMaleMiceNeural Stem CellsOxidopamineParkinson DiseaseRatsDopamineDopamine Plasma Membrane Transport ProteinsLevodopaOxidopamine

Identifiers

PMID27077649
PMCPMC4831749
OpenAlexW2338760546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.