ArticleRedox report : communications in free radical research2016
Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever.
Article in Redox report : communications in free radical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Evaluation of soluble transferrin receptor and malondialdehyde levels associated with ferroptosis in children with familial Mediterranean fever in remission.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome.Journal of medical biochemistry · 2021Article
- Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspectsTurkish journal of medical sciences · 2020Review
- Evaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel method.Northern clinics of Istanbul · 2019Article
- Does thiol-disulphide balance show oxidative stress in different MEFV mutations?Rheumatology international · 2018Article
- Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?Journal of Korean medical science · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
objectiveTo investigate the presence of oxidative stress (OS) in pregnant women with Familial Mediterranean fever (FMF) in the first trimester by evaluating thiol/disulphide homeostasis. STUDY
designA total of 31 pregnant women with a diagnosis of FMF, between 11(0) and 13(6) weeks of gestation, were compared with 51 healthy pregnant controls at the same gestational weeks. A recently defined method was used to measure plasma native thiol, total thiol and disulphide levels.
resultsThere were no differences between groups in terms of maternal age, body mass index and numbers of gravida and parity. Antenatal complications (45.2% vs. 9.8%, P = 0.001) and primary caesarean section (22.6% vs. 5.9%, P = 0.037) were higher in the FMF group. Pregnant women with FMF had significantly lower first trimester serum levels of native thiol (297.5 μmol/l (153.2-441.8) vs. 366.1 μmol/l (288.7-432.4), P = 0.000), total thiol (327.2 μmol/l (171.0-471.0) vs. 389.9 μmol/l (317.1-449.8), P = 0.000) and higher levels of disulphide (14.2 ± 4.5 μmol/l vs. 12.4 ± 3.4 μmol/l, P = 0.045). No differences were found in these parameters among FMF patients with and without antenatal complications.
conclusionsThe main outcome demonstrates a relation between OS and pregnant women with FMF in the first trimester of gestation. OS in the first trimester may be a major aetiological factor of unfavourable pregancy outcomes in this group of patients.
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