ArticleNature protocols2016
3D printing of versatile reactionware for chemical synthesis.
Article in Nature protocols, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Solvent-based post-processing to fill layer gaps in FFF-printed polypropylene fluidic chips and their application to flow injection analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Multi-Component 3D Bioprinted Platform with Sacrificial Matrix and Collagen-Based Bioinks for Skeletal Muscle Tissue Engineering.Polymers · 2026Article
- Protocellular energy transduction, information and fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Article
- Application of a fully 3D printed carbon electrode for the double potential step Chronoamperometric determination of 2,4-dinitrophenol in environmental water samples.Frontiers in chemistry · 2025Article
- 3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications.Chemistry, an Asian journal · 2024Review
- ERCAD: A Parametric Reactor Design Tool That Enables Rapid Prototyping and Optimization of Electrochemical Reactors through 3D Printing.ACS central science · 2024Article
- 3D-Printing of Hierarchical Porous Copper-Based Metal-Organic-Framework Structures for Efficient Fixed-Bed Catalysts.Chem & bio engineering · 2024Article
- Rapid Lewis Acid Screening and Reaction Optimization Using 3D-Printed Catalyst-Impregnated Stirrer Devices in the Synthesis of Heterocycles.The Journal of organic chemistry · 2023Article
- Cerium oxide nanoparticles: Synthesis methods and applications in wound healing.Materials today. Bio · 2023Review
- Wireless Electrochemical Reactor for Accelerated Exploratory Study of Electroorganic Synthesis.ACS central science · 2023Article
- Robotic Modules for the Programmable Chemputation of Molecules and Materials.ACS central science · 2023Review
- Processes for the 3D Printing of Hydrodynamic Flow-Focusing Devices.Micromachines · 2023Article
- 3D-Printing of Capsule Devices as Compartmentalization Tools for Supported Reagents in the Search of Antiproliferative Isatins.Pharmaceuticals (Basel, Switzerland) · 2023Article
- A 3D Printer in the Lab: Not Only a Toy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Review
- Additive manufacturing technology of polymeric materials for customized products: recent developments and future prospective.RSC advances · 2021Review
- Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications.Biomedicines · 2021Review
- Review
- 3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent decades, 3D printing (also known as additive manufacturing) techniques have moved beyond their traditional applications in the fields of industrial manufacturing and prototyping to increasingly find roles in scientific research contexts, such as synthetic chemistry. We present a general approach for the production of bespoke chemical reactors, termed reactionware, using two different approaches to extrusion-based 3D printing. This protocol describes the printing of an inert polypropylene (PP) architecture with the concurrent printing of soft material catalyst composites, using two different 3D printer setups. The steps of the PROCEDURE describe the design and preparation of a 3D digital model of the desired reactionware device and the preparation of this model for use with fused deposition modeling (FDM) type 3D printers. The protocol then further describes the preparation of composite catalyst-silicone materials for incorporation into the 3D-printed device and the steps required to fabricate a reactionware device. This combined approach allows versatility in the design and use of reactionware based on the specific needs of the experimental user. To illustrate this, we present a detailed procedure for the production of one such reactionware device that will result in the production of a sealed reactor capable of effecting a multistep organic synthesis. Depending on the design time of the 3D model, and including time for curing and drying of materials, this procedure can be completed in ∼3 d.
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