ArticlePeerJ2016
Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Anticancer activity and molecular docking of active ingredients from ethanolic extract of grapefruit peels against HepG2 cell.Scientific reports · 2026Article
- Chlorophyll Supplementation Delays Aging inNutrients · 2026Article
- Exploring natural colorants from plants to insects: chemistry, functions, and modern uses.RSC advances · 2026Review
- Phycochemistry and pharmacological significance of filamentous cyanobacterium Spirulina sp.Bioresources and bioprocessing · 2025Review
- Anti-Aging Potential of Avocado Oil via Its Antioxidant Effects.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Comparison of MicroalgaeMarine drugs · 2024Article
- Rosavin extends lifespan via the insulin/IGF-1 signaling pathway in Caenorhabditis elegans.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Article
- Evaluation of the In Vivo Anti-Atherosclerotic Activity of Quercetin Isolated from the Hairy Roots ofLife (Basel, Switzerland) · 2023Article
- Chlorophylls as Natural Bioactive Compounds Existing in Food By-Products: A Critical Review.Plants (Basel, Switzerland) · 2023Review
- Campomanesia adamantium O Berg. fruit, native to Brazil, can protect against oxidative stress and promote longevity.PloS one · 2023Article
- Development and characterization of chlorophyll-amended montmorillonite clays for the adsorption and detoxification of benzene.Water research · 2022Article
- Onion Vinegar Quality Evaluation and its Alleviate Oxidative Stress Mechanism in Caenorhabditis elegans Via SKN-1.Plant foods for human nutrition (Dordrecht, Netherlands) · 2022Article
- Oolonghomobisflavans exert neuroprotective activities in cultured neuronal cells and anti-aging effects inFrontiers in aging neuroscience · 2022Article
- Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials inMolecules (Basel, Switzerland) · 2021Review
- Sulforaphane promotesAging · 2021Article
- Baru Pulp (Biomolecules · 2020Article
- Plant and fungal products that extend lifespan inMicrobial cell (Graz, Austria) · 2020Review
- Carotenoids and Chlorophylls as Antioxidants.Antioxidants (Basel, Switzerland) · 2020Review
- Piquiá Shells (Oxidative medicine and cellular longevity · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Green vegetables are thought to be responsible for several beneficial properties such as antioxidant, anti-mutagenic, and detoxification activities. It is not known whether these effects are due to chlorophyll which exists in large amounts in many foods or result from other secondary metabolites. In this study, we used the model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo. We found that chlorophyll significantly improves resistance to oxidative stress. It also enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway. The results indicate that chlorophyll is absorbed by the worms and is thus bioavailable, constituting an important prerequisite for antioxidant and longevity-promoting activities inside the body. Our study thereby supports the view that green vegetables may also be beneficial for humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.