Evidence map›Paper›PMID 27076950›Full record

ArticleJournal of thoracic disease2016

Impact of attenuated plaques on TIMI grade flow and clinical outcomes of coronary artery disease patients: a systematic review and meta analysis.

Ruofei Jia, Xiaolu Nie, Hong Li, Huagang Zhu, Lianmei Pu, Xiang Li, Jing Han, Duo Yang, Shuai Meng, Zening Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruofei Jia1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Xiaolu Nie1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Hong Li1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Huagang Zhu1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Lianmei Pu1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Xiang Li1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Jing Han1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Duo Yang1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Shuai Meng1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Zening Jin1 Thirty-three ward, Department of emergency cardiology, Beijing Anzhen hospital, Capital Medical University, Beijing 100029, China ; 2 Center of Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlaques with a large necrotic core or lipid pool and thin-cap fibroatheroma manifest as attenuated plaques on intravascular ultrasound (IVUS). Their impact on TIMI grade flow and clinical outcomes remains undefined. We performed a systematic review and meta-analysis to summarize the association between attenuated plaque and distal embolization and clinical outcomes of coronary artery disease (CAD) from pooled data of published eligible cohort studies.

methodsWe searched the literature on TIMI grade flow and clinical outcomes on PubMed, Ovid, EMBASE, the Cochrane Library, CNKI and WanFang databases. Study heterogeneity and publication bias were estimated.

resultsA total of 3,833 patients were enrolled in nine studies. Five studies investigated TIMI grade flow and attenuated plaques. They revealed no difference in TIMI grade flow before percutaneous coronary intervention (PCI) between the attenuated and non-attenuated plaque group (RR =1.25; 95% CI: 0.65 to 2.41; P=0.50). After balloon dilation and stent implantation, the incidence of TIMI 0~2 grade flow in the attenuated plaque group was statistically significant higher than that of the non-attenuated plaque group (RR =4.73; 95% CI: 3.03 to 7.40; P<0.001). Five other studies investigated major cardiovascular events (MACEs) and attenuated plaques and found no difference in MACE rates within three years of follow up.

conclusionsOur study presents the evidence that plaque with ultrasound signal attenuation would induce slow/no reflow phenomenon and distal embolization during PCI, but this appearance has no impact on MACE rates within three years.

Indexed as

Attenuated plaque, intravascular ultrasound (IVUS)coronary artery disease (CAD)distal embolizationmajor adverse cardiac events (MACE)meta-analysis

Identifiers

PMID27076950
PMCPMC4805847

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.