Evidence map›Paper›PMID 27076897›Full record

ArticleInternational journal of preventive medicine2016

The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial.

Atefe Asgharian, Gholamreza Askari, Ahmad Esmailzade, Awat Feizi, Vida Mohammadi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 12 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 12 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  2. Gut Microbiota and Liver Health: Meta-Analysis ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Atefe AsgharianDepartment of Community Nutrition, Food Security Research Centre, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Treatment Affair, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Gholamreza AskariDepartment of Community Nutrition, Food Security Research Centre, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Ahmad EsmailzadeDepartment of Community Nutrition, Food Security Research Centre, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Awat FeiziDepartment of Community Nutrition, Food Security Research Centre, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Vida MohammadiDepartment of Community Nutrition, Food Security Research Centre, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRegarding to the growing prevalence of nonalcoholic fatty liver disease (NAFLD), concentrating on various strategies to its prevention and management seems necessary. The aim of this study was to determine the effects of symbiotic on C-reactive protein (CRP), liver enzymes, and ultrasound findings in patients with NAFLD.

methodsEighty NAFLD patients were enrolled in this randomized, double-blind, placebo-controlled clinical trial. Participants received symbiotic in form of a 500 mg capsule (containing seven species of probiotic bacteria and fructooligosaccharides) or a placebo capsule daily for 8 weeks. Ultrasound grading, CRP, and liver enzymes were evaluated at the baseline and the end of the study.

resultsIn the symbiotic group, ultrasound grade decreased significantly compared to baseline (P < 0.005) but symbiotic supplementation was not associated with changes in alanine aminotransferase (ALT) and aspartate transaminase (AST) levels. In the placebo group, there was no significant change in steatosis grade whereas ALT and AST levels were significantly increased (P = 0.002, P = 0.02, respectively). CRP values remained static in either group.

conclusionsSymbiotic supplementation improved steatosis in NAFLD patients and might be useful in the management of NAFLD or protective against its progression.

Indexed as

Liver steatosisnonalcoholic fatty liver diseasesymbiotic

Identifiers

PMID27076897
PMCPMC4809112
OpenAlexW2313249083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.