ArticleJournal of occupational medicine and toxicology (London, England)2016
Identification of metal sensitization in sarcoid-like metal-exposed patients by the MELISA® lymphocyte proliferation test - a pilot study.
Article in Journal of occupational medicine and toxicology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 38 citations in OpenAlex.
- Sarcoidosis risk among U.S. Veterans exposed to inorganic dust during military service.Annals of the American Thoracic Society · 2026Article
- Particles exposures and sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Sarcoidosis Induced by Metal Particles From a Left Elbow Prosthesis.Kidney medicine · 2025Article
- Lung fibrosis in sarcoidosis. Is there a place for antifibrotics?Frontiers in pharmacology · 2024Review
- Comparing [Heliyon · 2023Article
- Methods to Assess Proliferation of Stimulated Human Lymphocytes In Vitro: A Narrative Review.Cells · 2023Review
- Differential diagnosis of pulmonary sarcoidosis: a review.Frontiers in medicine · 2023Review
- The Role ofMicroorganisms · 2022Review
- Sarcoid-like reaction in patients with malignant tumors: Long-term clinical course and outcomes.Frontiers in medicine · 2022Article
- Differential immunological effects of silica nanoparticles on peripheral blood mononuclear cells of silicosis patients and controls.Frontiers in immunology · 2022Article
- Sarcoidosis: An Occupational Disease?Chest · 2021Review
- Simultaneous testing of immunological sensitization to multiple antigens in sarcoidosis reveals an association with inorganic antigens specifically related to a fibrotic phenotype.Clinical and experimental immunology · 2021Article
- Pneumoconiosis with a Sarcoid-Like Reaction Other than Beryllium Exposure: A Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2020Review
- Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients.Respiratory research · 2020Article
- Particle and vapor emissions from vat polymerization desktop-scale 3-dimensional printers.Journal of occupational and environmental hygiene · 2019Article
- The Occupational Burden of Nonmalignant Respiratory Diseases. An Official American Thoracic Society and European Respiratory Society Statement.American journal of respiratory and critical care medicine · 2019Review
- Interstitial lung diseases associated with metal content in silicone breast implants: a case series.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Repeated pulmonary exposures to zinc ions enhance inflammatory responses to subsequent metal exposures.Experimental lung researchArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary function is often affected by the inhalation of metal particles. The resulting pathology might trigger various lung diseases, e.g., parenchymal lung fibrosis and granulomatous lung disorders. We previously demonstrated that 6 % of tissue-proven sarcoid patients had a positive beryllium lymphocyte proliferation test (BeLPT), thus correcting the diagnosis to chronic beryllium disease. The aim of this study was to examine if MEmory Lymphocyte Immnuno Stimulation Assay (MELISA®), currently used for non-pulmonary diseases, can identify metals other than beryllium that can also trigger sensitization and induce granulomatous disease.
methodsThis pilot study included 13 sarcoid-like patients who underwent MELISA®. Eleven patients also underwent BeLPT. Biopsy samples were tested for metal content by scanning electron microscope. Eleven study patients had been exposed to metals at the workplace and 2 had silicone implants.
resultsTwo patients who had undergone BeLPT were positive for beryllium. MELISA® detected 9 patients (9/13, 69 %) who were positive for at least one of the tested metals: 4 reacted positively to nickel, 4 to titanium, 2 to chromium, 2 to beryllium, 2 to silica, and one each to palladium, mercury and lead.
conclusionIt is proposed that MELISA® can be exploited to also identify specific sensitization in individuals exposed to inhaled particles from a variety of metals.
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