ArticleInternational journal of medical sciences2016
Therapeutic Drug Monitoring of Vancomycin in Dermal Interstitial Fluid Using Dissolving Microneedles.
Article in International journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- AI-Ready Multimodal Wearable Biosensors Beyond Glucose: Biofluid Sampling, Sensor Fusion, and Clinical Translation.Biosensors · 2026Review
- Technical challenges and quality considerations for dissolving microneedles.International journal of pharmaceutics · 2026Article
- Seconds-Resolved Measurements of Vancomycin Transport from the Plasma to the Interstitial Fluid Highlight a Path Towards Real-Time Therapeutic Drug Monitoring.Sensors (Basel, Switzerland) · 2026Article
- Pilot phase clinical trial of a wearable, electrochemical aptamer-based patch for continuous drug concentration measurement.Nature biotechnology · 2026Article
- Fabrication and mechanical/biological evaluations of dissolving bird-bill microneedle arrays.Drug delivery and translational research · 2025Article
- Enhanced Interstitial Fluid Extraction and Rapid Analysis via Vacuum Tube-Integrated Microneedle Array Device.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Polymeric Microneedles for Health Care Monitoring: An Emerging Trend.ACS sensors · 2024Review
- Microneedle Sensors for Point-of-Care Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Development of a novel microneedle platform for biomarker assessment of atopic dermatitis patients.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases.Advanced healthcare materials · 2023Review
- Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects.Journal of pharmaceutical analysis · 2023Review
- Microneedle Array Technique for the Longitudinal Extraction of Interstitial Fluid without Hair Removal.Methods and protocols · 2022Article
- Enhancement strategies for transdermal drug delivery systems: current trends and applications.Drug delivery and translational research · 2022Article
- Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges.Pharmaceutics · 2021Review
- Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior ofDrug delivery · 2020Article
- Microneedle-based bioassays.Nanoscale advances · 2020Review
- Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin.Antibiotics (Basel, Switzerland) · 2020Article
- Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- Article
- Monitoring drug pharmacokinetics and immunologic biomarkers in dermal interstitial fluid using a microneedle patch.Biomedical microdevices · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo design an alternative painless method for vancomycin (VCM) monitoring by withdrawing interstitial fluid (ISF) the skin using dissolving microneedles (DMNs) and possibly replace the conventional clinical blood sampling method.
methodsMale Wistar rats were anesthetized with 50 mg/kg sodium pentobarbital. Vancomycin at 5 mg/mL in saline was intravenously administered via the jugular vein. ISF was collected from a formed pore at 15, 30, 45, 60, 75, 90, and 120 min after the DMNs was removed from the skin. In addition, 0.3 mL blood samples were collected from the left femoral vein.
resultsThe correlation between the plasma and ISF VCM concentrations was significantly strong (r = 0.676, p < 0.05). Microscopic observation of the skin after application of the DMNs demonstrated their safety as a device for sampling ISF.
conclusionA novel monitoring method for VCM was developed to painlessly determine concentrations in the ISF as opposed to blood sampling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.