ArticlePharmacognosy magazine
In vitro and In vivo Antioxidant Activity of Flavonoid Extracted from Mulberry Fruit (Morus alba L.).
Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Mulberry Extract Mitigates Glucose-Induced Oxidative Injury in Differentiated ARPE-19 Cells by Enhancing Antioxidant Defense: Implications for Diabetic Retinopathy.Food science & nutrition · 2025Article
- Refinement and Enhancement ofGenes · 2024Article
- Article
- Integrated transcriptomic and metabolomic analyses elucidate the mechanism of flavonoid biosynthesis in the regulation of mulberry seed germination under salt stress.BMC plant biology · 2024Article
- Fruit quality evaluation of different mulberry varieties.Frontiers in plant science · 2024Article
- Chemical Composition, Antioxidant Potentials, and Calcium Oxalate Anticrystallization Activity of Polyphenol and Saponin Fractions fromPlants (Basel, Switzerland) · 2022Article
- Untargeted Metabolomics Coupled with Chemometrics for Leaves and Stem Barks of DioeciousMetabolites · 2022Article
- Review
- Pharmacological Activities forFoods (Basel, Switzerland) · 2021Review
- Review
- Protective role of fermented mulberry leave extract in LPS‑induced inflammation and autophagy of RAW264.7 macrophage cells.Molecular medicine reports · 2020Article
- Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures.Antioxidants (Basel, Switzerland) · 2020Article
- Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four DifferentAntioxidants (Basel, Switzerland) · 2020Article
- Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage.Antioxidants (Basel, Switzerland) · 2020Review
- Integrated Transcriptomic and Un-Targeted Metabolomics Analysis Reveals Mulberry Fruit (International journal of molecular sciences · 2020Article
- Indirect regeneration and genetic fidelity analysis of acclimated plantlets through SCoT and ISSR markers inBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger Protects against Cerebral Ischemia in Metabolic Syndrome Rats.Oxidative medicine and cellular longevity · 2020Article
- Anti-obesity effect in high-fat-diet-induced obese C57BL/6 mice: Study of a novel extract from mulberry (Experimental and therapeutic medicine · 2019Article
- UP1306: A Composition Containing Standardized Extracts ofNutrients · 2019Article
- Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal Model of Menopause with Metabolic Syndrome.Oxidative medicine and cellular longevity · 2019Article
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7 authors.
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Abstract
backgroundMany plants possess antioxidants that exhibit additive or synergistic activities.
objectiveIn this study, an ethanol-extracted flavonoid extracted from mulberry fruit (FEM) was evaluated for the antioxidant activity in vitro and the hemolysis in red blood cell (RBC) and lipid peroxidation in liver in vivo. MATERIALS AND
methodsAntioxidant activities in vitro were measured by quantifying its 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, reducing power, and Fe(2+)-chelating ability. FEM inhibits hemolysis in RBCs and effects of lipid peroxidation in the liver were estimated.
resultsThe total content of flavonoid compounds was 187.23 mg of quercetin equivalents per grams dried material. In the in vitro assays, FEM demonstrated a strong antioxidant effect, especially in DPPH scavenging activity and reducing power. Mouse RBC hemolysis induced by H2O2 was significantly inhibited by FEM in a dose- and time-dependent manner. The effects of FEM on lipid peroxidation in liver, mitochondria, and microsome were investigated. The percentage of inhibition at high concentration (100 μg/mL) of FEM was 45.51%, 39.36%, and 42.78% for liver, mitochondria, and microsomes, respectively. These results suggest that the FEM possesses a strong antioxidant activity both in vivo and in vitro. SUMMARY: The total content of flavonoid compounds in mulberry fruit was 187.23 mg/g dried materialFEM showed a strong antioxidant effect, especially in 2,2-diphenyl-1-picrylhydrazyl scavenging activity and reducing powerMouse red blood cell hemolysis induced by H2O2 was significantly inhibited by FEM in a dose- and time-dependent mannerThe inhibition percentage at high concentration of FEM was 45.51%, 39.36%, and 42.78% for mouse's liver, mitochondrial, and microsomes, respectively. Abbreviations used: FEM: Flavonoid Extracted from Mulberry fruit, H2O2: Hydrogen peroxide, DPPH: 2,2-diphenyl-1-picrylhydrazyl, EDTA: Ethylene diamine tetraacetic acid, MDA: malondialdehyde, TBA: 2-thiobarbituric acid, RBC: Red blood cells, DNJ: 1-deoxynojirimycin, LDL: low density lipoprotein, ROS: reactive oxygen species, EDTA2Na: Ethylenediaminetetraacetic acid disodium salt.
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