Evidence map›Paper›PMID 27076596›Full record

SynthesisThe European respiratory journal2016

A 380-gene meta-signature of active tuberculosis compared with healthy controls.

Simon Blankley, Christine M Graham, Joe Levin, Jacob Turner, Matthew P R Berry, Chloe I Bloom, Zhaohui Xu, Virgina Pascual, Jacques Banchereau, Damien Chaussabel and 5 more

Abstract readLetterMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The European respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Doxycycline host-directed therapy in human pulmonary tuberculosis.The Journal of clinical investigation · 2021
    Trial
  3. Article
  4. Host- and pathogen-related determinants of pulmonaryEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Transfer transcriptomic signatures for infectious diseases.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Article
  20. Immune Subtyping in Latent Tuberculosis.Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Simon BlankleyLaboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory (formerly The MRC National Institute for Medical Research), London, UK.
Christine M GrahamLaboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory (formerly The MRC National Institute for Medical Research), London, UK.
Joe LevinLaboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory (formerly The MRC National Institute for Medical Research), London, UK.
Jacob TurnerBaylor Research Institute, Baylor Scott & White, Dallas, TX, USA.
Matthew P R BerryLaboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory (formerly The MRC National Institute for Medical Research), London, UK Dept of Respiratory Medicine, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK.
Chloe I BloomLaboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory (formerly The MRC National Institute for Medical Research), London, UK.
Zhaohui XuBaylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM, Dallas, TX, USA.
Virgina PascualBaylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM, Dallas, TX, USA.
Jacques BanchereauThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Damien ChaussabelSidra Medical and Research Center, Doha, Qatar.
Ronan BreenDept of Respiratory Medicine, King's College London, London, UK.
George SantisDept of Respiratory Medicine, King's College London, London, UK Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
Derek M BlankenshipBaylor Research Institute, Baylor Scott & White, Dallas, TX, USA.
Marc LipmanDept of Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK Division of Medicine, University College London, London, UK.
Anne O'GarraLaboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory (formerly The MRC National Institute for Medical Research), London, UK Dept of Medicine, NHLI, Imperial College, London, UK anne.ogarra@crick.ac.uk.

Funding

Department of HealthMedical Research Council MC_U117565642Medical Research Council MR/J010723/1Medical Research Council U117565642
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Host-Pathogen InteractionsGene Expression ProfilingHumansSignal TransductionTranscriptomeTuberculosis

Identifiers

PMID27076596
PMCPMC4892351

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.