ArticleThe European respiratory journal2016
Natural variability of lung function in young healthy school children.
Article in The European respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of antiretroviral therapy on longitudinal lung function trends in older children and adolescents with HIV-infection.PloS one · 2019Trial
- Real-world feasibility of adapted European Respiratory Society asthma diagnosis guidelines for school-aged children.ERJ open research · 2026Article
- Quantifying lung growth with CT-derived intrapulmonary vascular volume: a cross-sectional study.BMC medical imaging · 2025Article
- Natural variability of lung function in primary ciliary dyskinesia: longitudinal analysis from the PROVALF-PCD cohort.ERJ open research · 2025Article
- Current Challenges in Pediatric Asthma.Children (Basel, Switzerland) · 2024Review
- Lung Function in Children with Primary Ciliary Dyskinesia.Children (Basel, Switzerland) · 2023Article
- Lung function from school age to adulthood in primary ciliary dyskinesia.The European respiratory journal · 2022Article
- Benefits of Telemonitoring of Pulmonary Function-3-Month Follow-Up of Home Electronic Spirometry in Patients with Duchenne Muscular Dystrophy.Journal of clinical medicine · 2022Article
- Indoor Air Pollution, Related Human Diseases, and Recent Trends in the Control and Improvement of Indoor Air Quality.International journal of environmental research and public health · 2020Review
- The health and social implications of household air pollution and respiratory diseases.NPJ primary care respiratory medicine · 2019Review
- Inter-test reproducibility of the lung clearance index measured by multiple breath washout.The European respiratory journal · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Knowledge about long-term variability of lung function in healthy children is essential when monitoring and treating those with respiratory disease over time. The aim of this study was to define the natural variability in spirometry in young children after an interval of 12 months.The Size and Lung function In Children study was a prospective study designed to assess spirometry and body size, shape and composition in a multi-ethnic population of London school children. 14 schools with a wide range of socioeconomic circumstances were recruited. Spirometric and anthropometric assessments and parental questionnaires pertaining to respiratory symptoms, previous medical history, pubertal status and socioeconomic circumstances were completed at baseline and ∼1 year later.Technically acceptable spirometry data on two occasions ∼1 year apart (range 9-16 months) were available in 758 children (39% boys, mean±sd age 8.1±1.6 years), 593 of whom were classified as "healthy". Mean±sd within-subject between-test variability was 0.05±0.6 z-scores, with 95% of all the children achieving a between-test variability within ±1.2 z-scores (equating to ∼13% predicted).Natural variations of up to 1.2 z-scores occur in healthy children over ∼1 year. These must be considered when interpreting results from annual reviews in those with lung disease who are otherwise stable, if unnecessary further investigations or changes in treatment are to be avoided.
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Registered trials
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