Trial reportGut1989
Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer.
Trial report in Gut, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 95 citations in OpenAlex.
- Effects of calcisorb on fecal bile acids and fatty acids in human volunteers.Digestive diseases and sciences · 1996Trial
- Trial
- Anticarcinogenic Effect of Corn Tortilla Against 1,2-Dimethylhydrazine (DMH)-Induced Colon Carcinogenesis in Sprague-Dawley Rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2015Article
- Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse.Nutrition and cancer · 2011Article
- Protective effects of diets supplemented with omega-3 polyunsaturated fatty acids and calcium against colorectal tumor formation.Digestive diseases and sciences · 2008Article
- Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence.European journal of clinical nutrition · 2003Review
- Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas.Digestive diseases and sciences · 1999Article
- Nutritional strategies in the prevention of colorectal cancer.Current gastroenterology reports · 1999Review
- Colon cancer: polyps, prevention, and politics.Transactions of the American Clinical and Climatological Association · 1998Review
- Article
- Article
- Epithelial cell proliferation in the sigmoid colon of patients with adenomatous polyps increases during oral calcium supplementation.British journal of cancer · 1993Article
- Article
- Gastroenterology.Postgraduate medical journal · 1990Review
- Short-term tests and long-term prospects for colon cancer prevention.Medical oncology and tumor pharmacotherapy · 1990Review
- Intervention studies in adenoma patients.World journal of surgeryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings suggest that supplemental calcium could lower the abnormally high proliferation rate found in the colonic mucosa of subjects at high risk for colon cancer. In this double blind controlled study, this effect in volunteers previously operated upon for a colorectal adenocarcinoma was tested. Thirty subjects were randomised to receive either elemental calcium 1200 mg/day or a placebo. Mucosal proliferation was measured with tritiated thymidine labelling before and after the 30 day intervention period. Diets, faecal pH and the concentration of calcium and bile acids in the aqueous phase of feaces were also measured. Labelling index did not differ significantly in the two groups before intervention (placebo 4.0(2.4) v calcium 4.9(2.9), but the difference approached significance afterwards (4.4(2.4) v 6.5(3.4), p = 0.06). Individual changes occurring with intervention were tabulated and comparison of the means for the groups was not significant (delta = 0.3 vs delta = 1.8, p = 0.11). Calcium concentration, faecal pH and deoxycholic acid concentration increased in the calcium group (p = 0.02, 0.005 and 0.004 respectively). Calcium does not show any effect in decreasing colonic mucosal proliferation in this high risk group for colon cancer; it may increase faecal pH and the production of deoxycholic acid in the colon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.