Evidence map›Paper›PMID 27076128›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2016

Proteomic Monitoring of B Cell Immunity.

Radwa Ewaisha, Karen S Anderson

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Radwa EwaishaCenter for Personalized Diagnostics, School of Life Sciences, The Biodesign Institute, Arizona State University, 876401, Tempe, AZ, 85287, USA.
Karen S AndersonCenter for Personalized Diagnostics, School of Life Sciences, The Biodesign Institute, Arizona State University, 876401, Tempe, AZ, 85287, USA. Karen.Anderson.1@asu.edu.

Funding

Novel approaches to study immune responses to post translational modifications for cancer detectionU01CA214201 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI ANDERSON, KAREN SUE, LABAER, JOSHUA · 2016 to 2021
$2.6M
NCI NIH HHS U01 CA11734NCI NIH HHS U01 CA214201
6 · The paper itself

Abstract

Immune monitoring is critical in settings of infection, autoimmunity, and cancer, but our understanding of the diversity of the antibody immune repertoire has been limited to selected target antigens and epitopes. Development of new vaccines requires monitoring of B cell immunity and identification of candidate antigens. As vaccines become more complex, novel techniques are required for monitoring the diversity of the B cell immune response. Since antibodies recognize both linear and conformational protein and glycoprotein epitopes, recent advances in proteomic and glycomic technologies for rapid display of antigenic structures are leading to methods for proteome-wide immune monitoring. Here, we review different approaches for protein display for immune monitoring, and provide methods for in situ protein display for the rapid detection and validation of antibody repertoires.

Indexed as

AnimalsB-LymphocytesCell Surface Display TechniquesHumansImmunoblottingProteomicsAntibodyB cellEpitopeImmune monitoringImmunityPhage displayProtein arraysProtein display

Identifiers

PMID27076128
PMCPMC5558855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.