ArticleScientific reports2016
Reduced expression of cytochrome oxidases largely explains cAMP inhibition of aerobic growth in Shewanella oneidensis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- The Cyclic Adenosine Monophosphate Phosphodiesterase CpdA Modulates cAMP Homeostasis, Stress Adaptability, Biofilm Formation, Motility, Quorum Sensing and Antibiotic Resistance ofJournal of microbiology and biotechnology · 2026Article
- Regulation of iron homeostasis by Fur and atypical response regulator SsoR via derepressor-inhibitor oscillation inApplied and environmental microbiology · 2025Article
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- The electron transport chain ofApplied and environmental microbiology · 2024Article
- Bacterial TANGO2 homologs are heme-trafficking proteins that facilitate biosynthesis of cytochromesmBio · 2023Article
- A Common Target of Nitrite and Nitric Oxide for Respiration Inhibition in Bacteria.International journal of molecular sciences · 2022Article
- Pleiotropic Effects of Hfq on the CytochromeApplied and environmental microbiology · 2022Article
- NapB Restores cytochrome c biosynthesis in bacterial dsbD-deficient mutants.Communications biology · 2022Article
- Article
- Aerobic Respiration and Its Regulation in the Metal ReducerFrontiers in microbiology · 2021Article
- Promoting Extracellular Electron Transfer ofFrontiers in microbiology · 2021Article
- Free Rather Than Total Iron Content Is Critically Linked to the Fur Physiology inFrontiers in microbiology · 2020Article
- Complex Oxidation of ApocytochromesApplied and environmental microbiology · 2019Article
- CytochromesApplied and environmental microbiology · 2018Article
- Dissociation between Iron and Heme Biosyntheses Is Largely Accountable for Respiration Defects ofApplied and environmental microbiology · 2018Article
- Partially Reciprocal Replacement of FlrA and FlrC in Regulation of Shewanella oneidensis Flagellar Biosynthesis.Journal of bacteriology · 2018Article
- Investigation of a spontaneous mutant reveals novel features of iron uptake in Shewanella oneidensis.Scientific reports · 2017Article
- Loss of OxyR reduces efficacy of oxygen respiration in Shewanella oneidensis.Scientific reports · 2017Article
- CRP Regulates D-Lactate Oxidation inFrontiers in microbiology · 2017Article
- NapB in excess inhibits growth of Shewanella oneidensis by dissipating electrons of the quinol pool.Scientific reports · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibition of bacterial growth under aerobic conditions by elevated levels of cyclic adenosine 3',5'-monophosphate (cAMP), first revealed more than 50 years ago, was attributed to accumulation of toxic methylglyoxal (MG). Here, we report a Crp-dependent mechanism rather than MG accumulation that accounts for the phenotype in Shewanella oneidensis, an emerging research model for the bacterial physiology. We show that a similar phenotype can be obtained by removing CpdA, a cAMP phosphodiesterase that appears more effective than its Escherichia coli counterpart. Although production of heme c and cytochromes c is correlated well with cAMP levels, neither is sufficient for the retarded growth. Quantities of overall cytochromes c increased substantially in the presence of elevated cAMP, a phenomenon resembling cells respiring on non-oxygen electron acceptors. In contrast, transcription of Crp-dependent genes encoding both cytochromes bd and cbb3 oxidases is substantially repressed under the same condition. Overall, our results suggest that cAMP of elevated levels drives cells into a low-energetic status, under which aerobic respiration is inhibited.
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