ArticleThe Journal of nutrition2016
An Increase in Dietary Quality Is Associated with Favorable Plasma Biomarkers of the Brain-Adipose Axis in Apparently Healthy US Women.
Article in The Journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Dietary patterns and associations with biomarkers of inflammation in adults: a systematic review of observational studies.Nutrition journal · 2021Pooled it
- Associations between common contraceptive use and circulating inflammatory biomarkers.American journal of epidemiology · 2025Article
- Associations Between Diet Quality and Proinflammatory Cytokines in Newly Diagnosed Head and Neck Cancer Survivors.Current developments in nutrition · 2023Article
- Adherence to Healthy Lifestyle Prior to Infection and Risk of Post-COVID-19 Condition.JAMA internal medicine · 2023Article
- Overall diet quality and proinflammatory diet in relation to risk of obstructive sleep apnea in 3 prospective US cohorts.The American journal of clinical nutrition · 2022Article
- Trauma, psychological distress and markers of systemic inflammation among US women: A longitudinal study.Psychoneuroendocrinology · 2022Article
- Depression, religiosity, and telomere length in the Study on Stress, Spirituality, and Health (SSSH).International journal of mental health and addiction · 2022Article
- The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization.Cardiovascular diabetology · 2021Article
- A Dietary Inflammatory Index and associations with C-reactive protein in a general adult population.European journal of nutrition · 2021Article
- Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?International journal of molecular sciences · 2020Review
- Estimated Number of Lifetime Ovulatory Years and Its Determinants in Relation to Levels of Circulating Inflammatory Biomarkers.American journal of epidemiology · 2020Article
- Beneficial Fatty Acid Ratio ofFoods (Basel, Switzerland) · 2020Article
- Prospective Study of Long-Term Interrelationships Among Adiposity-Associated Biomarkers in Women.Obesity (Silver Spring, Md.) · 2020Article
- Processed Meat Intake and Risk of Chronic Obstructive Pulmonary Disease among Middle-aged Women.EClinicalMedicine · 2019Article
- The Mind-Body Study: study design and reproducibility and interrelationships of psychosocial factors in the Nurses' Health Study II.Cancer causes & control : CCC · 2019Article
- Change in Plant-Based Diet Quality Is Associated with Changes in Plasma Adiposity-Associated Biomarker Concentrations in Women.The Journal of nutrition · 2019Article
- Association between dietary intake and inflammatory markers: results from the CoLaus study.Public health nutrition · 2019Article
- Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals.Scientific reports · 2019Article
- A Network Analysis of Biomarkers for Type 2 Diabetes.Diabetes · 2019Article
- Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe associations between long-term dietary quality and biomarkers of the brain-adipose axis have not been examined.
objectiveWe evaluated both cross-sectional and longitudinal associations between dietary quality and several biomarkers involved in the brain-adipose axis.
methodsIn the Nurses' Health Study II, 831 women [baseline mean age: 45 y; body mass index (BMI; in kg/m(2)): 24.6] were randomly selected from women who provided 2 fasting blood samples in 1996-1999 and 2010-2011 to measure plasma concentrations of leptin, soluble leptin receptor (sOB-R), adiponectin, insulin, retinol binding protein-4 (RBP-4), interleukin-6 (IL-6), and C-reactive protein (CRP). Dietary quality was assessed by the Alternative Healthy Eating Index (AHEI-2010) with the use of semiquantitative food-frequency questionnaires administered in 1995 and 2011. We used linear mixed models to evaluate the cross-sectional associations between dietary quality and biomarker concentrations. We also examined change in dietary quality in relation to change in biomarker concentrations.
resultsIn cross-sectional analyses that compared the highest with the lowest quintile of AHEI-2010, we observed significantly lower leptin (P-trend < 0.0001), insulin (P-trend < 0.0001), and CRP (P-trend = 0.02) and significantly higher sOB-R (P-trend < 0.0001) and adiponectin (P-trend = 0.0003). These associations, except for CRP, remained significant after adjustment for BMI. In longitudinal analyses, women in the highest quintile of AHEI-2010 score change (most improvement) had a 13% increase in leptin, compared with a 42% increase (P-trend < 0.0001) in the lowest quintile (least improvement). The corresponding multivariable-adjusted percentage changes for other biomarkers were 4% compared with -1% for sOB-R (P-trend = 0.04), 14% compared with 6% for adiponectin (P-trend = 0.02), and -11% compared with 16% for CRP (P-trend = 0.02). Adjustment for interim weight change attenuated these associations. No associations were observed for RBP-4 or IL-6.
conclusionImprovement in dietary quality was associated with favorable profiles of several biomarkers of the brain-adipose axis in women.
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