ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016
Bone marrow lesions and subchondral bone pathology of the knee.
Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Knee Intraosseous Injections: A Systematic Review of Clinical Evidence of Different Treatment Alternatives.Cartilage · 2021Pooled it
- Bone bruise in anterior cruciate ligament rupture entails a more severe joint damage affecting joint degenerative progression.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Pooled it
- Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow-up.International orthopaedics · 2021Trial
- Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study.International orthopaedics · 2021Trial
- Article
- Clinical and Radiological Outcomes of Oral Bisphosphonate Therapy Combined with Conservative Treatment in Subchondral Bone Marrow Edema of the Knee: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Surgical treatments of bone marrow lesions.Journal of experimental orthopaedics · 2026Review
- Relationships Among Bone Marrow Lesions, Cartilage Improvement, and Short- to Midterm Patient-Reported Outcomes After Opening-Wedge High Tibial Osteotomy.Orthopaedic journal of sports medicine · 2026Article
- Patients with preoperative bone marrow oedema benefit more substantially from medial meniscus posterior root repair.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Bone Marrow Edema and Tyrosine Kinase Inhibitors Treatment in Chronic Myeloid Leukemia.Diagnostics (Basel, Switzerland) · 2025Article
- Distribution of Bone Contusion Patterns in Knees with Acute Isolated Posterior Cruciate Ligament Tears.Orthopaedic journal of sports medicine · 2025Article
- Subchondral Phosphate Injection During Hip Arthroscopy Safely Treats Acetabular Bone Marrow Lesions in Early Osteoarthritis.Journal of clinical medicine · 2025Article
- Using magnetic resonance imaging-based subregional texture analysis models to classify knee osteoarthritis severity by compartment.Scientific reports · 2025Article
- Arthroscopic-Assisted Management of Subchondral Bone Marrow Lesions of the Knee.Arthroscopy techniques · 2025Article
- Article
- Bone bruise assessment in knees with ACL lesions: semi-quantitative scores outperform quantitative evaluation.Archives of orthopaedic and trauma surgery · 2025Article
- Conservative treatments of bone marrow lesions.Journal of experimental orthopaedics · 2025Article
- Bone marrow lesions in osteoarthritis: biomarker or treatment target? A narrative review.Skeletal radiology · 2025Review
- A nosographic and etiopathogenetic framework for subchondral bone marrow lesions in the knee: A narrative review.Journal of experimental orthopaedics · 2025Article
- Subchondral bone: An emerging target for the treatment of articular surface lesions of the knee.Journal of experimental orthopaedics · 2024Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow lesions (BMLs) around the knee are a common magnetic resonance imaging (MRI) finding. However, despite the growing interest on BMLs in multiple pathological conditions, they remain controversial not only for the still unknown role in the etiopathological processes, but also in terms of clinical impact and treatment. The differential diagnosis includes a wide range of conditions: traumatic contusion and fractures, cyst formation and erosions, hematopoietic and infiltrated marrow, developmental chondroses, disuse and overuse, transient bone marrow oedema syndrome and, lastly, subchondral insufficiency fractures and true osteonecrosis. Regardless the heterogeneous spectrum of these pathologies, a key factor for patient management is the distinction between reversible and irreversible conditions. To this regard, MRI plays a major role, leading to the correct diagnosis based on recognizable typical patterns that have to be considered together with coexistent abnormalities, age, and clinical history. Several treatment options have been proposed, from conservative to surgical approaches. In this manuscript the main lesion patterns and their management have been analysed to provide the most updated evidence for the differential diagnosis and the most effective treatment.
Indexed as
Identifiers
27075892What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.