ArticleMalaria journal2016
Malaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spatial and spatio-temporal methods for mapping malaria risk: a systematic review.BMJ global health · 2020Pooled it
- Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia.Malaria journal · 2021Trial
- Geographical patterns of malaria transmission based on serological markers for falciparum and vivax malaria in Ratanakiri, Cambodia.Malaria journal · 2016Trial
- Anopheles ecology and serological evidence of malaria exposure in clinically malaria-free areas of Menoreh Hills Central Java, Indonesia.Scientific reports · 2026Article
- Comparison of fine-scale malaria strata derived from population survey data collected using RDTs, microscopy and qPCR in South-Eastern Tanzania.Malaria journal · 2024Article
- Key considerations, target product profiles, and research gaps in the application of infrared spectroscopy and artificial intelligence for malaria surveillance and diagnosis.Malaria journal · 2023Review
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- Spatiotemporal dynamics of malaria in Zanzibar, 2015-2020.BMJ global health · 2023Article
- Altitude, not potential larval habitat availability, explains pronounced variation in Plasmodium falciparum infection prevalence in the western Kenya highlands.PLOS global public health · 2023Article
- Identification of factors associated with residual malaria transmission using school-based serological surveys in settings pursuing elimination.Malaria journal · 2022Article
- Spatial-temporal pattern of malaria in Burkina Faso from 2013 to 2020.Parasite epidemiology and control · 2022Article
- Spatial-temporal clustering of malaria using routinely collected health facility data on the Kenyan Coast.Malaria journal · 2021Article
- The assembly effect: the connectedness between populations is a double-edged sword for public health interventions.Malaria journal · 2021Article
- Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in MatureFrontiers in cellular and infection microbiology · 2021Article
- Targeting Malaria Hotspots to Reduce Transmission Incidence in Senegal.International journal of environmental research and public health · 2020Article
- How to Estimate Optimal Malaria Readiness Indicators at Health-District Level: Findings from the Burkina Faso Service Availability and Readiness Assessment (SARA) Data.International journal of environmental research and public health · 2020Article
- Mosquito Exposure and Malaria Morbidity: A Microlevel Analysis of Household Mosquito Populations and Malaria in a Population-Based Longitudinal Cohort in Western Kenya.The Journal of infectious diseases · 2020Article
- Article
- Prevalence ofThe American journal of tropical medicine and hygiene · 2020Article
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13 authors.
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Abstract
backgroundTargeted malaria control interventions are expected to be cost-effective. Clinical, parasitological and serological markers of malaria transmission have been used to detect malaria transmission hotspots, but few studies have examined the relationship between the different potential markers in low transmission areas. The present study reports on the relationships between clinical, parasitological, serological and entomological markers of malaria transmission in an area of low transmission intensity in Coastal Kenya.
methodsLongitudinal data collected from 831 children aged 5-17 months, cross-sectional survey data from 800 older children and adults, and entomological survey data collected in Ganze on the Kenyan Coast were used in the present study. The spatial scan statistic test used to detect malaria transmission hotspots was based on incidence of clinical malaria episodes, prevalence of asymptomatic asexual parasites carriage detected by microscopy and polymerase chain reaction (PCR), seroprevalence of antibodies to two Plasmodium falciparum merozoite antigens (AMA1 and MSP1-19) and densities of Anopheles mosquitoes in CDC light-trap catches.
resultsThere was considerable overlapping of hotspots by these different markers, but only weak to moderate correlation between parasitological and serological markers. PCR prevalence and seroprevalence of antibodies to AMA1 or MSP1-19 appeared to be more sensitive markers of hotspots at very low transmission intensity.
conclusionThese findings may support the choice of either serology or PCR as markers in the detection of malaria transmission hotspots for targeted interventions.
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