ArticleHypertension research : official journal of the Japanese Society of Hypertension2016
Effects of xanthine oxidase inhibitors on renal function and blood pressure in hypertensive patients with hyperuricemia.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
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- The association among uric acid, microalbumin and estimated glomerular filtration rate in hypertensive patients: a case control study.BMC cardiovascular disorders · 2023Article
- Sacha Inchi Oil Press-Cake Protein Hydrolysates Exhibit Anti-Hyperuricemic Activity via Attenuating Renal Damage and Regulating Gut Microbiota.Foods (Basel, Switzerland) · 2022Article
- The Pattern of Allopurinol Prescription Among Chronic Kidney Disease Patients in a Tertiary Care Centre: A Single-Centre Experience.International journal of general medicine · 2021Article
- Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group.Frontiers in cardiovascular medicine · 2021Article
- Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging.Molecules (Basel, Switzerland) · 2019Review
- Oxidative stress in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Hyperuricemia and Hypertension: Links and Risks.Integrated blood pressure control · 2019Review
- The impact of serum uric acid reduction on renal function and blood pressure in chronic kidney disease patients with hyperuricemia.Clinical and experimental nephrology · 2018Observational
- Effects of uric acid on vascular endothelial function from bedside to bench.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Evaluation of the Effectiveness of Xanthine Oxidoreductase Inhibitors on Haemodialysis Patients using a Marginal Structural Model.Scientific reports · 2017Article
- Dietary and commercialized fructose: Sweet or sour?International urology and nephrology · 2017Review
- Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review.Journal of advanced research · 2017Review
- Association of serum uric acid with subsequent arterial stiffness and renal function in normotensive subjects.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Impaired xanthine oxidoreductase (XOR)-mediated nitrite reductase activity possibly involved in the lack of antihypertensive effects of XOR inhibitors.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Oxidative Stress and Hypertensive Diseases.The Medical clinics of North America · 2017Review
- Effects of uric-acid-lowering therapy on renal outcomes: the future looks promising.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
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9 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia may promote the progression of hypertension and renal dysfunction. However, the effects of hyperuricemia treatment on blood pressure and renal function in adult hypertensive patients with hyperuricemia remain unclear. A total of 137 hypertensive patients with hyperuricemia (96 men and 41 women; mean age of 67 years) who recently started taking xanthine oxidase inhibitors (allopurinol or febuxostat) as outpatients were recruited. Serum uric acid level, estimated glomerular filtration rate (eGFR, ml min(-1) per 1.73 m(2)) and blood pressure (mm Hg) were retrospectively compared immediately before and shortly after starting treatment with xanthine oxidase inhibitors. The mean blood pressure and the eGFR immediately before starting treatment were 128/71 mm Hg and 44.6 ml min(-1) per 1.73 m(2), respectively. Although the eGFR decreased from 46.6 to 44.6 ml min(-1) per 1.73 m(2) before starting treatment with xanthine oxidase inhibitors, it increased to 46.2 ml min(-1) per 1.73 m(2) (P=0.001, compared with immediately before treatment) without any significant changes in blood pressure after the administration of xanthine oxidase inhibitors. Multiple regression analysis revealed that the increase in eGFR after starting xanthine oxidase inhibitor treatment positively correlated with the changes in systolic blood pressure and negatively correlated with the changes in uric acid levels and the use of renin-angiotensin system inhibitors. These results suggest that xanthine oxidase inhibitors may delay the progression of renal dysfunction in adult hypertensive patients with hyperuricemia.
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