ArticleGenetics2016
Background Selection in Partially Selfing Populations.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- ThebioRxiv : the preprint server for biology · 2026Article
- Estimating the Reduction in Genetic Diversity from Background Selection under Non-equilibrium Demography and Partial Selfing.Molecular biology and evolution · 2026Article
- Genomic perspectives on the inference of evolutionary changes in ecological life-history traits.Quantitative plant biology · 2026Review
- Article
- Mating systems and recombination landscape strongly shape genetic diversity and selection in wheat relatives.Evolution letters · 2024Article
- Polygenic selection to a changing optimum under self-fertilisation.PLoS genetics · 2024Article
- Weak response to selection on stigma-anther distance in a primarily selfing population of yellow monkeyflower.Proceedings. Biological sciences · 2024Article
- The infinitesimal model with dominance.Genetics · 2023Article
- Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes.PLoS genetics · 2023Article
- Article
- Mating system and speciation I: Accumulation of genetic incompatibilities in allopatry.PLoS genetics · 2022Article
- Pollinator loss causes rapid adaptive evolution of selfing and dramatically reduces genome-wide genetic variability.Evolution; international journal of organic evolution · 2022Article
- Article
- Article
- Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations.Genetics · 2021Article
- A simple expression for the strength of selection on recombination generated by interference among mutations.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly.Molecular biology and evolution · 2021Article
- Genetic variation in an ephemeral mudflat species: The role of the soil seed bank and dispersal in river and secondary anthropogenic habitats.Ecology and evolution · 2020Article
- Selective Sweeps Under Dominance and Inbreeding.G3 (Bethesda, Md.) · 2020Article
- Partial Selfing Can Reduce Genetic Loads While Maintaining Diversity During Experimental Evolution.G3 (Bethesda, Md.) · 2019Article
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1 author.
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Abstract
Self-fertilizing species often present lower levels of neutral polymorphism than their outcrossing relatives. Indeed, selfing automatically increases the rate of coalescence per generation, but also enhances the effects of background selection and genetic hitchhiking by reducing the efficiency of recombination. Approximations for the effect of background selection in partially selfing populations have been derived previously, assuming tight linkage between deleterious alleles and neutral loci. However, loosely linked deleterious mutations may have important effects on neutral diversity in highly selfing populations. In this article, I use a general method based on multilocus population genetics theory to express the effect of a deleterious allele on diversity at a linked neutral locus in terms of moments of genetic associations between loci. Expressions for these genetic moments at equilibrium are then computed for arbitrary rates of selfing and recombination. An extrapolation of the results to the case where deleterious alleles segregate at multiple loci is checked using individual-based simulations. At high selfing rates, the tight linkage approximation underestimates the effect of background selection in genomes with moderate to high map length; however, another simple approximation can be obtained for this situation and provides accurate predictions as long as the deleterious mutation rate is not too high.
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