ArticleScientific reports2016
Alternative promoters of Peg3 with maternal specificity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- PEG3 controls lipogenesis through ACLY.PloS one · 2021Article
- Transcription factor expression defines subclasses of developing projection neurons highly similar to single-cell RNA-seq subtypes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Downregulated PEG3 ameliorates cardiac fibrosis and myocardial injury in mice with ischemia/reperfusion through the NF-κB signaling pathway.Journal of bioenergetics and biomembranes · 2020Article
- Rbfox1 Is Expressed in the Mouse Brain in the Form of Multiple Transcript Variants and Contains Functional E Boxes in Its Alternative Promoters.Frontiers in molecular neuroscience · 2020Article
- Long noncoding RNA ZNF667-AS1 reduces tumor invasion and metastasis in cervical cancer by counteracting microRNA-93-3p-dependent PEG3 downregulation.Molecular oncology · 2019Article
- Differentially methylated region in bovine MIMT1 detected by small-scale whole-genome methylation sequencing.Journal of applied genetics · 2019Article
- Article
- Role of the zinc finger and SCAN domain-containing transcription factors in cancer.American journal of cancer research · 2019Review
- The imprinted gene Pw1/Peg3 regulates skeletal muscle growth, satellite cell metabolic state, and self-renewal.Scientific reports · 2018Article
- Intergenic and intronic DNA hypomethylated regions as putative regulators of imprinted domains.Epigenomics · 2018Article
- Enhancer-driven alternative promoters of imprinted genes.PloS one · 2018Article
- Circular RNA identified from Peg3 and Igf2r.PloS one · 2018Article
- Transcription-driven DNA methylation setting on the mouse Peg3 locus.Epigenetics · 2017Article
- Article
- Parental and sexual conflicts over the Peg3 imprinted domain.Scientific reports · 2016Article
- Sex and Tissue Specificity of Peg3 Promoters.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Peg3 (paternally expressed gene 3) is an imprinted gene localized within an evolutionarily conserved 500-kb domain in human chromosome 19q13.4 and mouse proximal chromosome 7. In the current study, we have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3. These alternative promoters are localized within the 200-kb upstream region of human and mouse PEG3, which is well conserved and thus predicted to harbor several cis-regulatory elements for the PEG3 domain. In the mouse, two of these alternative promoters drive maternal-specific expression of Peg3 specifically in the hypothalamus of the adult brain, while the remaining third promoter drives bi-allelic expression of Peg3 with a paternal bias only in the neonatal-stage brain. In human, an alternative transcript is also detected at relatively very low levels in adult brain and placenta. Overall, the identification of alternative promoters in both mouse and human models suggests that these alternative promoters may be functionally selected features for the PEG3 imprinted domain during mammalian evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.