ArticleJournal of clinical laboratory analysis2016
Analysis of 25-Hydroxyvitamin D Status According to Age, Gender, and Seasonal Variation.
Article in Journal of clinical laboratory analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Vitamin D Level and Clinical Outcomes of Assisted Reproductive Treatment: A Systematic Review and Dose-Response Meta-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Real-World Assessment of Osteoporosis-Related Polymorphisms: Negative Findings for Osteoporosis and an Exploratory Association with Vitamin D.Life (Basel, Switzerland) · 2026Article
- Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency.Journal of bone and mineral metabolism · 2025Article
- Article
- Impact of home confinement due to the COVID-19 outbreak on vitamin D levels and trends among children with pneumonia aged 1-35 months.Pediatric discovery · 2024Article
- Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy.Antioxidants (Basel, Switzerland) · 2023Review
- Serum 25-hydroxyvitamin D status of a large Chinese population from 30 provinces by LC-MS/MS measurement for consecutive 3 years: differences by age, sex, season and province.European journal of nutrition · 2023Article
- Increased Carcinoembryonic Antigen (CEA) Level Is Highly Associated with Low Skeletal Muscle Mass in Asymptomatic Adults: A Population-Based Study.Journal of clinical medicine · 2022Article
- Sex and Age Differences Modulate Association of Vitamin D with Serum Triglyceride Levels.Journal of personalized medicine · 2022Article
- Serum vitamin D level correlates with disease activity and health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis.Zeitschrift fur Rheumatologie · 2022Article
- How can the orthopedic surgeon ensure optimal vitamin D status in patients operated for an osteoporotic fracture?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Review
- Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients.Nutrients · 2021Review
- Vitamin D: A simpler alternative to tocilizumab for trial in COVID-19?Medical hypotheses · 2020Article
- Status and influential factors of vitamin D among children aged 0 to 6 years in a Chinese population.BMC public health · 2020Article
- Influence of fall environment and fall direction on risk of injury among pre-frail and frail adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- The Role of Skeletal Muscle in Maintaining Vitamin D Status in Winter.Current developments in nutrition · 2019Review
- Article
- Clinical and Vitamin Response to a Short-Term Multi-Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses.Molecular nutrition & food research · 2018Article
- Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.Nature communications · 2018Article
- Predictors of 25-hydroxyvitamin D status among individuals with metabolic syndrome: a cross-sectional study.Diabetology & metabolic syndrome · 2018Article
Corrections and comments
- Erratum issuedCorrigendum.2017
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of age, gender, and seasonal variation on human levels of 25-hydroxyvitamin D (25(OH)D) are not well understood. In this study, we aimed to investigate 25(OH)D status according to these factors in a Korean population.
methodsA total of 303,943 serum 25(OH)D levels were measured using an electrochemiluminescence immunoassay between October 2011 and May 2014. Potential participants were ineligible for the study if they had significant renal, hepatic, or thyroid dysfunction, as well as any major ongoing disease that could influence serum 25(OH)D levels.
resultsA total of 95,137 subjects (49,662 men and 45,475 women) were included in this study. The mean 25(OH)D levels were higher in men (42.4 nmol/l) than in women (32.9 nmol/l, P < 0.001). Among the men and women, 73.0% and 88.9%, respectively, had 25(OH)D levels <50 nmol/l, whereas only 3.8% of men and 1.4% of women had levels >75 nmol/l. The highest mean 25(OH)D value was noted in individuals aged ≥70 for both genders. The proportion of those with 25(OH)D levels <50 nmol/l appeared to be higher among younger subjects (P < 0.001). Lastly, there were significant differences between 25(OH)D levels in individuals during summer to fall and winter to spring in both genders, indicating seasonal periodicity (P < 0.001).
conclusionsSerum 25(OH)D status varied according to gender, age, and season. Therefore, analyses of vitamin D status require individualized gender, age, and seasonally adjusted thresholds. Clinicians should consider these factors when determining optimal serum 25(OH)D levels in clinical practice.
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