Evidence map›Paper›PMID 27075512›Full record

ArticleScientific reports2016

DRAMP: a comprehensive data repository of antimicrobial peptides.

Linlin Fan, Jian Sun, Meifeng Zhou, Jie Zhou, Xingzhen Lao, Heng Zheng, Hanmei Xu

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed.

  1. Artificial intelligence catalyzes antimicrobial peptide design.Synthetic and systems biotechnology · 2027
    Review
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  3. Article
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  19. The intricacies ofFrontiers in microbiology · 2025
    Review
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linlin FanSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Jian SunSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Meifeng ZhouMOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Jie ZhouCenter of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Xingzhen LaoSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Heng ZhengSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Hanmei XuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.

Funding

Sensitivity to Intravenous Ethanol: Neuroimaging and Behavioral PhenotypesR21AA020304 · NIAAA · THE MIND RESEARCH NETWORK · PI CLAUS, ERIC D, HENDERSHOT, CHRISTIAN S · 2011 to 2012
$434k
NIAAA NIH HHS R21 AA020304
6 · The paper itself

Abstract

The growing problem of antibiotic-resistant microorganisms results in an urgent need for substitutes to conventional antibiotics with novel modes of action and effective activities. Antimicrobial peptides (AMPs), produced by a wide variety of living organisms acting as a defense mechanism against invading pathogenic microbes, are considered to be such promising alternatives. AMPs display a broad spectrum of antimicrobial activity and a low propensity for developing resistance. Therefore, a thorough understanding of AMPs is essential to exploit them as antimicrobial drugs. Considering this, we developed a comprehensive user-friendly data repository of antimicrobial peptides (DRAMP), which holds 17349 antimicrobial sequences, including 4571 general AMPs, 12704 patented sequences and 74 peptides in drug development. Entries in the database have detailed annotations, especially detailed antimicrobial activity data (shown as target organism with MIC value) and structure information. Annotations also include accession numbers crosslinking to Pubmed, Swiss-prot and Protein Data Bank (PDB). The website of the database comes with easy-to-operate browsing as well as searching with sorting and filtering functionalities. Several useful sequence analysis tools are provided, including similarity search, sequence alignment and conserved domain search (CD-Search). DRAMP should be a useful resource for the development of novel antimicrobial peptide drugs.

Indexed as

Databases, FactualAnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesHumansMicrobial Sensitivity TestsAnti-Infective AgentsAntimicrobial Cationic Peptides

Identifiers

PMID27075512
PMCPMC4830929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.