Evidence map›Paper›PMID 27075504›Full record

ArticleScientific reports2016

Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting.

Hua-Jie Wang, Ying Cao, Cai-Feng Wang, Shi-Zhong Cui, Li-Wei Mi, Teruo Miyazawa

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hua-Jie WangCenter for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
Ying CaoCenter for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
Cai-Feng WangCenter for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
Shi-Zhong CuiCenter for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
Li-Wei MiCenter for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
Teruo MiyazawaCenter for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into "nanomedicine" based on the understanding of Trojan horse-anti-tumor mechanism of inorganic nano-medicines. Moreover, we reported the green and facile synthesis route of mono-dispersed and rod-like zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites. We found that the nanocomposites exhibited high-efficiency killing ability to tumor cells through lipid peroxidation mediated-membrane disintegration route. The safety studies in BALB/c mice didn't detect injection anaphylaxis, hemolysis and cytotoxicity. More interestingly, the nano-composites could specially accumulate in liver and kidney, which will be helpful for targeting cure to these regional cancers.

Indexed as

NanomedicineAnimalsAntineoplastic AgentsCadmium ChlorideCell Line, TumorDrug Delivery SystemsKidneyLiverMice, Inbred BALB CNanocompositesZeinZinc OxideAntineoplastic AgentsCadmium ChlorideZeinZinc Oxide

Identifiers

PMID27075504
PMCPMC4831000

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.