Evidence map›Paper›PMID 27075359›Full record

ArticleThe Journal of membrane biology2016

Expression of KCNA5 Protein in Human Mammary Epithelial Cell Line Associated with Caveolin-1.

Jia Liu, Chao Qu, Hongyan Li, Yejun Zhang, Jia Sun, Shuo Yang, Jing Liu, Lijia An, Wei Zou

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In one paragraph

Article in The Journal of membrane biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jia LiuDepartment of Biological Science and Technology, Dalian University of Technology, Dalian, 116024, China.
Chao QuCollege of Life Science, Liaoning Normal University, No. 1, The South Street of Liushu, Dalian, 116029, China.
Hongyan LiCollege of Life Science, Liaoning Normal University, No. 1, The South Street of Liushu, Dalian, 116029, China.
Yejun ZhangCollege of Life Science, Liaoning Normal University, No. 1, The South Street of Liushu, Dalian, 116029, China.
Jia SunCollege of Life Science, Liaoning Normal University, No. 1, The South Street of Liushu, Dalian, 116029, China.
Shuo YangCollege of Life Science, Liaoning Normal University, No. 1, The South Street of Liushu, Dalian, 116029, China.
Jing LiuCentre of Regenerative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Lijia AnDepartment of Biological Science and Technology, Dalian University of Technology, Dalian, 116024, China.
Wei ZouCollege of Life Science, Liaoning Normal University, No. 1, The South Street of Liushu, Dalian, 116029, China. yuan_zhang84@yahoo.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated potassium (Kv) channels are involved in the proliferation and transformation of mammary epithelial cells. They are thought to be related to the development of breast carcinoma, although the exact role they play in this event remains unclear. In this study, we investigated whether the expression and function of Kv channels is associated with Caveolin-1 (Cav-1, a principal component of caveolae) in different cell lines. We found that expression of Cav-1 correlated with the expression of Kv channels in mammary epithelial cells (MCF10A, MCF10A-ST1, and MCF7), and silencing of Cav-1 inhibited the expression of KCNA5 (voltage-gated shaker-related subfamily A, member 5). Immunofluorescence analysis indicated the colocalization of KCNA5 with Cav-1, whereas immunoprecipitation suggested a possible interaction between the two proteins. Overall, our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells.

Indexed as

Gene ExpressionCaveolin 1Cell LineCell Line, TumorEpithelial CellsHumansIon Channel GatingKv1.5 Potassium ChannelMammary Glands, HumanPotassium Channels, Voltage-GatedProtein BindingProtein TransportCaveolin 1Kv1.5 Potassium ChannelPotassium Channels, Voltage-GatedCaveolin-1Human mammary epithelium cell lineKCNA5 protein

Identifiers

PMID27075359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.