Evidence map›Paper›PMID 27075264›Full record

ReviewNature reviews. Gastroenterology & hepatology2016

Management of refractory typical GERD symptoms.

Emidio Scarpellini, Daphne Ang, Ans Pauwels, Adriano De Santis, Tim Vanuytsel, Jan Tack

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04660019 (Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04660019 nacompletednot on this mapstarted 2020, after this paper: background citation

Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease

TypeinterventionalSponsorTaipei Medical University WanFang HospitalRan2020 to 2022Enrolled48ConditionsGastroesophageal Reflux Disease (GERD), NeurologyArmsScalp and auricular acupuncture, Seed acupressure
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Emidio ScarpelliniTranslational Research in Gastrointestinal Disorders (TARGID), University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Daphne AngDivision of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore 529889.
Ans PauwelsTranslational Research in Gastrointestinal Disorders (TARGID), University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Adriano De SantisDivision of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore 529889.
Tim VanuytselTranslational Research in Gastrointestinal Disorders (TARGID), University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Jan TackTranslational Research in Gastrointestinal Disorders (TARGID), University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
KU Leuven · BEChangi General Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of patients with refractory GERD (rGERD) is a major clinical challenge for gastroenterologists. In up to 30% of patients with typical GERD symptoms (heartburn and/or regurgitation), acid-suppressive therapy does not provide clinical benefit. In this Review, we discuss the current management algorithm for GERD and the features and management of patients who do not respond to treatment (such as those individuals with an incorrect diagnosis of GERD, inadequate PPI intake, persisting acid reflux and persisting weakly acidic reflux). Symptom response to existing surgical techniques, novel antireflux procedures, and the value of add-on medical therapies (including prokinetics and reflux inhibitors) for rGERD symptoms are discussed. Pharmaceutical agents targeting oesophageal sensitivity, a condition that can contribute to symptom generation in rGERD, are also discussed. Finally, on the basis of available published data and our expert opinion, we present an outline of a current, usable algorithm for management of patients with rGERD that considers the timing and diagnostic use of pH-impedance monitoring on or off PPI, additional diagnostic tests, the clinical use of baclofen and the use of add-on neuromodulators (tricyclic agents and selective serotonin reuptake inhibitors).

Indexed as

AlginatesAlgorithmsAntacidsBaclofenChronic DiseaseEsophagoscopyGastroesophageal RefluxGastrointestinal AgentsGastroscopyHumansIsoxazolesMuscle Relaxants, CentralNeurotransmitter AgentsPhosphinic AcidsPropylaminesTriazolesAlginatesAntacidsarbaclofen placarbilAZD2066BaclofenGastrointestinal AgentsIsoxazoleslesogaberanMuscle Relaxants, CentralNeurotransmitter AgentsPhosphinic AcidsPropylaminesTriazoles

Identifiers

PMID27075264
OpenAlexW2335985676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.