ArticleJournal of the Royal Society, Interface2016
Estimating biologically relevant parameters under uncertainty for experimental within-host murine West Nile virus infection.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 71 citations in OpenAlex.
- How robust are estimates of key parameters in standard viral dynamic models?PLoS computational biology · 2024Article
- Shifting the paradigm in RNA virus detection: integrating nucleic acid testing and immunoassays through single-molecule digital ELISA.Frontiers in immunology · 2023Review
- Identifiability of parameters in mathematical models of SARS-CoV-2 infections in humans.Scientific reports · 2022Article
- Review
- Mechanistic Modeling of SARS-CoV-2 and Other Infectious Diseases and the Effects of Therapeutics.Clinical pharmacology and therapeutics · 2021Review
- Article
- A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2.PLoS biology · 2021Article
- Early events in hepatitis B infection: the role of inoculum dose.Proceedings. Biological sciences · 2021Article
- Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference.PLoS computational biology · 2021Article
- Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.CPT: pharmacometrics & systems pharmacology · 2020Article
- Article
- Validated Models of Immune Response to Virus Infection.Current opinion in systems biology · 2018Article
- Mathematical modeling of within-host Zika virus dynamics.Immunological reviews · 2018Review
- Early HIV infection predictions: role of viral replication errors.SIAM journal on applied mathematics · 2018Article
- Influenza Virus Infection Model With Density Dependence Supports Biphasic Viral Decay.Frontiers in microbiology · 2018Article
- Understanding Immunity through the Lens of Disease Ecology.Trends in immunology · 2017Review
- Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response.Journal of the Royal Society, Interface · 2017Article
- Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Zika viral dynamics and shedding in rhesus and cynomolgus macaques.Nature medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
West Nile virus (WNV) is an emerging pathogen that has decimated bird populations and caused severe outbreaks of viral encephalitis in humans. Currently, little is known about the within-host viral kinetics of WNV during infection. We developed mathematical models to describe viral replication, spread and host immune response in wild-type and immunocompromised mice. Our approach fits a target cell-limited model to viremia data from immunocompromised knockout mice and an adaptive immune response model to data from wild-type mice. Using this approach, we first estimate parameters governing viral production and viral spread in the host using simple models without immune responses. We then use these parameters in a more complex immune response model to characterize the dynamics of the humoral immune response. Despite substantial uncertainty in input parameters, our analysis generates relatively precise estimates of important viral characteristics that are composed of nonlinear combinations of model parameters: we estimate the mean within-host basic reproductive number,R0, to be 2.3 (95% of values in the range 1.7-2.9); the mean infectious virion burst size to be 2.9 plaque-forming units (95% of values in the range 1.7-4.7); and the average number of cells infected per infectious virion to be between 0.3 and 0.99. Our analysis gives mechanistic insights into the dynamics of WNV infection and produces estimates of viral characteristics that are difficult to measure experimentally. These models are a first step towards a quantitative understanding of the timing and effectiveness of the humoral immune response in reducing host viremia and consequently the epidemic spread of WNV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.