Evidence map›Paper›PMID 27074951›Full record

ArticleBMC infectious diseases2016

Emerging pan-resistance in Trichosporon species: a case report.

Claudy Oliveira dos Santos, Jan G Zijlstra, Robert J Porte, Greetje A Kampinga, Anne D van Diepeningen, Bhanu Sinha, Erik Bathoorn

Erratum issuedOpen access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Journal of fungi (Basel, Switzerland) · 2026
    Article
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  4. Mass spectrometry in research laboratories and clinical diagnostic: a new era in medical mycology.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Claudy Oliveira dos SantosDepartment of Medical Microbiology (EB 80), University Medical Center Groningen, P.O. Box 30 001, 9700 RB, Groningen, The Netherlands. c.oliveira.dos.santos@umcg.nl.
Jan G ZijlstraDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Robert J PorteDepartment of Hepatobiliary Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Greetje A KampingaDepartment of Medical Microbiology (EB 80), University Medical Center Groningen, P.O. Box 30 001, 9700 RB, Groningen, The Netherlands.
Anne D van DiepeningenCBS-KNAW Fungal Biodiversity Center, Utrecht, The Netherlands.
Bhanu SinhaDepartment of Medical Microbiology (EB 80), University Medical Center Groningen, P.O. Box 30 001, 9700 RB, Groningen, The Netherlands.
Erik BathoornDepartment of Medical Microbiology (EB 80), University Medical Center Groningen, P.O. Box 30 001, 9700 RB, Groningen, The Netherlands.
University Medical Center Groningen · NLWesterdijk Fungal Biodiversity Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrichosporon species are ubiquitously spread and known to be part of the normal human flora of the skin and gastrointestinal tract. Trichosporon spp. normally cause superficial infections. However, in the past decade Trichosporon spp. are emerging as opportunistic agents of invasive fungal infections, particularly in severely immunocompromised patients. Clinical isolates are usually sensitive to triazoles, but strains resistant to multiple triazoles have been reported. CASE PRESENTATION: We report a high-level pan-azole resistant Trichosporon dermatis isolate causing an invasive cholangitis in a patient after liver re-transplantation. This infection occurred despite of fluconazole and low dose amphotericin B prophylaxis, and treatment with combined liposomal amphotericin B and voriconazole failed.

conclusionThis case and recent reports in literature show that not only bacteria are evolving towards pan-resistance, but also pathogenic yeasts. Prudent use of antifungals is important to withstand emerging antifungal resistance.

Indexed as

Amphotericin BAntifungal AgentsCholangitisDrug Resistance, FungalHepatic EncephalopathyHumansLiver CirrhosisLiver TransplantationMaleMicrobial Sensitivity TestsMiddle AgedPeritonitisPhylogenyTrichosporonTrichosporonosisVoriconazoleAmphotericin BAntifungal Agentsliposomal amphotericin BVoriconazoleAntifungal stewardshipDisseminated trichosporonosisInvasive fungal diseaseLiver transplantTrichosporon dermatis

Identifiers

PMID27074951
PMCPMC4831108
OpenAlexW2336076027

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.