Evidence map›Paper›PMID 27074938›Full record

Trial reportClinical and vaccine immunology : CVI2016

Protease Inhibitors Do Not Affect Antibody Responses to Pneumococcal Vaccination.

Indhira De La Rosa, Iona M Munjal, Maria Rodriguez-Barradas, Xiaoying Yu, Liise-Anne Pirofski, Daniel Mendoza

Open access · diamondAbstract readClinical Trial
In one paragraph

Trial report in Clinical and vaccine immunology : CVI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Indhira De La RosaDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Iona M MunjalAlbert Einstein College of Medicine, Bronx, New York, USA.
Maria Rodriguez-BarradasDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Xiaoying YuDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Liise-Anne PirofskiAlbert Einstein College of Medicine, Bronx, New York, USA.
Daniel MendozaDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA Daniel.Mendoza@bcm.edu.
Albert Einstein College of Medicine · USBaylor College of Medicine · USMichael E. DeBakey VA Medical Center · US

Funding

Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Research Training in Infections and ImmunityT32AI055413 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GIORDANO, THOMAS P, MYSOREKAR, INDIRA U · 2003 to 2024
$3.2M
Effects of aging and HIV infection on the response to pneumococcal vaccineR01AG045044 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PIROFSKI, LIISE-ANNE · 2014 to 2018
$2.5M
Antibody immunity to serotype 3 Streptococcus pneumoniaeR56AI104234 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PIROFSKI, LIISE-ANNE · 2013 to 2013
$407k
NIAID NIH HHS P30 AI036211NIAID NIH HHS R56 AI104234NIAID NIH HHS T32 AI055413NIA NIH HHS R01 AG045044
6 · The paper itself

Abstract

HIV(+) subjects on optimal antiretroviral therapy have persistently impaired antibody responses to pneumococcal vaccination. We explored the possibility that this effect may be due to HIV protease inhibitors (PIs). We found that in humans and mice, PIs do not affect antibody production in response to pneumococcal vaccination.

Indexed as

AnimalsAntibodies, BacterialAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountFemaleHIV InfectionsHIV Protease InhibitorsHumansImmunoglobulin GImmunoglobulin MMaleMicePneumococcal InfectionsPneumococcal VaccinesRitonavirStreptococcus pneumoniaeAntibodies, BacterialHIV Protease InhibitorsImmunoglobulin GImmunoglobulin MPneumococcal VaccinesRitonavir

Identifiers

PMID27074938
PMCPMC4895006
OpenAlexW2335865596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.