ArticleBiophysical journal2016
Cooperative Clustering Digitizes Biochemical Signaling and Enhances its Fidelity.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Nanoscale protein clustering modulates the input-output response of cellular signalling pathways.Scientific reports · 2026Article
- Lifetime of actin-dependent protein nanoclusters.Biophysical journal · 2023Article
- Correction of multiple-blinking artifacts in photoactivated localization microscopy.Nature methods · 2022Article
- The Role of Protein and Lipid Clustering in Lymphocyte Activation.Frontiers in immunology · 2021Review
- Article
- The Interplay of Structural and Cellular Biophysics Controls Clustering of Multivalent Molecules.Biophysical journal · 2019Article
- Inferring a nonlinear biochemical network model from a heterogeneous single-cell time course data.Scientific reports · 2018Article
- 3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse.Scientific reports · 2017Article
- A Bayesian cluster analysis method for single-molecule localization microscopy data.Nature protocols · 2016Article
- C2-domain mediated nano-cluster formation increases calcium signaling efficiency.Scientific reports · 2016Article
- Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters.Biophysical journal · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many membrane-bound molecules in cells form small clusters. It has been hypothesized that these clusters convert an analog extracellular signal into a digital intracellular signal and that this conversion increases signaling fidelity. However, the mechanism by which clusters digitize a signal and the subsequent effects on fidelity remain poorly understood. Here we demonstrate using a stochastic model of cooperative cluster formation that sufficient cooperation leads to digital signaling. We show that despite reducing the number of output states, which decreases fidelity, digitization also reduces noise in the system, which increases fidelity. The tradeoff between these effects leads to an optimal cluster size that agrees with experimental measurements.
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Registered trials
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