ArticleeLife2016
Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed.
- Lack of specificity of planarian progenitor responses to injury in regeneration.bioRxiv : the preprint server for biology · 2026Article
- Dynamic cell fate transitions during morphallactic regeneration.Nature communications · 2026Article
- Canonical WNT signalling governs Echinococcus metacestode development.PLoS pathogens · 2026Article
- RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a.Nature communications · 2026Article
- 4D single-cell spatial transcriptomics reveals dynamic morphogenetic gradients and regenerative domains in planarians.GigaScience · 2026Article
- The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning.PLoS biology · 2025Article
- egal-1 and microtubules promote regeneration polarity in planarians.Development (Cambridge, England) · 2025Article
- Planarian microtubules form a network within muscle and regulate injury-induced genes essential for regeneration patterning.Development (Cambridge, England) · 2025Article
- Article
- Molecular Mechanism of Metformin Regulating the Regeneration of PlanarianInternational journal of molecular sciences · 2025Article
- Pluripotent Stem Cell Plasticity is Sculpted by a Slit-Independent Robo Pathway in a Regenerative Animal.bioRxiv : the preprint server for biology · 2025Article
- map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration.PLoS genetics · 2025Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer.Current medicinal chemistry · 2025Article
- Article
- Therapeutic advances of targeting receptor tyrosine kinases in cancer.Signal transduction and targeted therapy · 2024Review
- A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- PTK7: an underestimated contributor to human cancer.Frontiers in oncology · 2024Review
- BMP suppresses WNT to integrate patterning of orthogonal body axes in adult planarians.PLoS genetics · 2023Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mechanisms enabling positional identity re-establishment are likely critical for tissue regeneration. Planarians use Wnt/beta-catenin signaling to polarize the termini of their anteroposterior axis, but little is known about how regeneration signaling restores regionalization along body or organ axes. We identify three genes expressed constitutively in overlapping body-wide transcriptional gradients that control trunk-tail positional identity in regeneration. ptk7 encodes a trunk-expressed kinase-dead Wnt co-receptor, wntP-2 encodes a posterior-expressed Wnt ligand, and ndl-3 encodes an anterior-expressed homolog of conserved FGFRL/nou-darake decoy receptors. ptk7 and wntP-2 maintain and allow appropriate regeneration of trunk tissue position independently of canonical Wnt signaling and with suppression of ndl-3 expression in the posterior. These results suggest that restoration of regional identity in regeneration involves the interpretation and re-establishment of axis-wide transcriptional gradients of signaling molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.