ArticleOncotarget2016
Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Yeast strain development and process intensification in high-gravity fermentation.FEMS yeast research · 2026Review
- Transcriptional profiling reveals the role of Candida albicans Rap1 in oxidative stress response.Bioscience reports · 2024Article
- Harnessing alkaline-pH regulatable promoters for efficient methanol-free expression of enzymes of industrial interest in Komagataella Phaffii.Microbial cell factories · 2024Article
- Oxidative Stress and Bio-Regulation.International journal of molecular sciences · 2024Review
- Antifungal Activity of Cedrol fromPlants (Basel, Switzerland) · 2024Article
- Adaptive response to wine selective pressures shapes the genome of aMicrobial genomics · 2021Article
- Review
- Understanding the Impact of Industrial Stress Conditions on Replicative Aging inFrontiers in fungal biology · 2021Review
- Article
- Aneuploidy and Ethanol Tolerance inFrontiers in genetics · 2019Article
- Article
- Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy.Cell cycle (Georgetown, Tex.) · 2017Review
- The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells.Oncotarget · 2017Article
- Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts.Archives of microbiology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Industrial yeast strains of economic importance used in winemaking and beer production are genomically diverse and subjected to harsh environmental conditions during fermentation. In the present study, we investigated wine yeast adaptation to chronic mild alcohol stress when cells were cultured for 100 generations in the presence of non-cytotoxic ethanol concentration. Ethanol-induced reactive oxygen species (ROS) and superoxide signals promoted growth rate during passages that was accompanied by increased expression of sirtuin proteins, Sir1, Sir2 and Sir3, and DNA-binding transcription regulator Rap1. Genome-wide array-CGH analysis revealed that yeast genome was shaped during passages. The gains of chromosomes I, III and VI and significant changes in the gene copy number in nine functional gene categories involved in metabolic processes and stress responses were observed. Ethanol-mediated gains of YRF1 and CUP1 genes were the most accented. Ethanol also induced nucleolus fragmentation that confirms that nucleolus is a stress sensor in yeasts. Taken together, we postulate that wine yeasts of different origin may adapt to mild alcohol stress by shifts in intracellular redox state promoting growth capacity, upregulation of key regulators of longevity, namely sirtuins and changes in the dosage of genes involved in the telomere maintenance and ion detoxification.
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