ArticleThe American journal of drug and alcohol abuse2016
Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: a pilot study.
Article in The American journal of drug and alcohol abuse, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Sleep quality of adult recreational cannabis users: a systematic review of literature.Trends in psychiatry and psychotherapy · 2025Pooled it
- Trial
- Reductions in cannabis use are associated with improvements in anxiety, depression, and sleep quality, but not quality of life.Journal of substance abuse treatment · 2017Trial
- Sleep regularity and duration are associated with depression severity in a nationally representative United States sample.Neurobiology of sleep and circadian rhythms · 2025Article
- UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Epilepsy.Brain and behavior · 2025Observational
- Pharmacological management of pediatric insomnia.Frontiers in sleep · 2024Review
- The Effect of Cannabis Use on Depression.Cureus · 2024Article
- Review
- Cannabis and sleep disorders: not ready for prime time? A qualitative scoping review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Modulation of Endocannabinoid System Components in Depression: Pre-Clinical and Clinical Evidence.International journal of molecular sciences · 2022Review
- Circulating endocannabinoids and prospective risk for depression in trauma-injury survivors.Neurobiology of stress · 2021Article
- Article
- Cannabis use and sleep: Expectations, outcomes, and the role of age.Addictive behaviors · 2021Article
- Down and High: Reflections Regarding Depression and Cannabis.Frontiers in psychiatry · 2021Review
- Onset of regular cannabis use and young adult insomnia: an analysis of shared genetic liability.Sleep · 2020Article
- The Endocannabinoid System May Modulate Sleep Disorders in Aging.Current neuropharmacology · 2020Review
- Exploring Interventions for Sleep Disorders in Adolescent Cannabis Users.Medical sciences (Basel, Switzerland) · 2018Review
- Changes in marijuana use symptoms and emotional functioning over 28-days of monitored abstinence in adolescent marijuana users.Psychopharmacology · 2017Article
- Cannabinoids in hair and their prospective association with mental and physical health outcomes in adolescents.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCannabis has been shown to affect sleep in humans. Findings from animal studies indicate that higher endocannabinoid levels promote sleep, suggesting that chronic use of cannabis, which downregulates endocannabinoid activity, may disrupt sleep.
objectivesThis study sought to determine if past-year cannabis use and genes that regulate endocannabinoid signaling, FAAH rs324420 and CNR1 rs2180619, predicted sleep quality. As depression has been previously associated with both cannabis and sleep, the secondary aim was to determine if depressive symptoms moderated or mediated these relationships.
methodsData were collected from 41 emerging adult (ages 18-25) cannabis users. Exclusion criteria included Axis I disorders (besides SUD) and medical and neurologic disorders. Relationships were tested using multiple regressions, controlling for demographic variables, past-year substance use, and length of cannabis abstinence.
resultsGreater past-year cannabis use and FAAH C/C genotype were associated with poorer sleep quality. CNR1 genotype did not significantly predict sleep quality. Depressive symptoms moderated the relationship between cannabis use and sleep at a nonsignificant trend level, such that participants with the higher cannabis use and depressive symptoms reported the more impaired sleep. Depressive symptoms mediated the relationship between FAAH genotype and sleep quality.
conclusionsThis study demonstrates a dose-dependent relationship between chronic cannabis use and reported sleep quality, independent of abstinence length. Furthermore, it provides novel evidence that depressive symptoms mediate the relationship between FAAH genotype and sleep quality in humans. These findings suggest potential targets to impact sleep disruptions in cannabis users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.